Biological aspects of reactive nitrogen species

Rakesh P. Patel, Joanne McAndrew, Hassan Sellak, C. Roger White, Hanjoong Jo, Bruce A. Freeman, Victor M. Darley-Usmar

Research output: Contribution to journalReview article

339 Citations (Scopus)

Abstract

Nitric oxide (NO) plays an important role as a cell-signalling molecule, anti-infective agent and, as most recently recognised, an antioxidant. The metabolic fate of NO gives rise to a further series of compounds, collectively known as the reactive nitrogen species (RNS), which possess their own unique characteristics. In this review we discuss this emerging aspect of the NO field in the context of the formation of the RNS and what is known about their effects on biological systems. While much of the insight into the RNS has been gained from the extensive chemical characterisation of these species, to reveal biological consequences this approach must be complemented by direct measures of physiological function. Although we do not know the consequences of many of the dominant chemical reactions of RNS an intriguing aspect is now emerging. This review will illustrate how, when specificity and amplification through cell signalling mechanisms are taken into account, the less significant reactions, in terms of yield or rates, can explain many of the biological responses of exposure of cells or physiological systems to RNS. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)385-400
Number of pages16
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1411
Issue number2-3
DOIs
StatePublished - May 5 1999

Fingerprint

Reactive Nitrogen Species
Cell signaling
Nitric Oxide
Biological systems
Anti-Infective Agents
Amplification
Chemical reactions
Antioxidants
Molecules

Keywords

  • Apoptosis
  • Cell signaling
  • Heme protein
  • Inflammation
  • Nitric oxide
  • Nitrotyrosine
  • Peroxynitrite
  • Superoxide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

Patel, R. P., McAndrew, J., Sellak, H., White, C. R., Jo, H., Freeman, B. A., & Darley-Usmar, V. M. (1999). Biological aspects of reactive nitrogen species. Biochimica et Biophysica Acta - Bioenergetics, 1411(2-3), 385-400. https://doi.org/10.1016/S0005-2728(99)00028-6

Biological aspects of reactive nitrogen species. / Patel, Rakesh P.; McAndrew, Joanne; Sellak, Hassan; White, C. Roger; Jo, Hanjoong; Freeman, Bruce A.; Darley-Usmar, Victor M.

In: Biochimica et Biophysica Acta - Bioenergetics, Vol. 1411, No. 2-3, 05.05.1999, p. 385-400.

Research output: Contribution to journalReview article

Patel, RP, McAndrew, J, Sellak, H, White, CR, Jo, H, Freeman, BA & Darley-Usmar, VM 1999, 'Biological aspects of reactive nitrogen species', Biochimica et Biophysica Acta - Bioenergetics, vol. 1411, no. 2-3, pp. 385-400. https://doi.org/10.1016/S0005-2728(99)00028-6
Patel RP, McAndrew J, Sellak H, White CR, Jo H, Freeman BA et al. Biological aspects of reactive nitrogen species. Biochimica et Biophysica Acta - Bioenergetics. 1999 May 5;1411(2-3):385-400. https://doi.org/10.1016/S0005-2728(99)00028-6
Patel, Rakesh P. ; McAndrew, Joanne ; Sellak, Hassan ; White, C. Roger ; Jo, Hanjoong ; Freeman, Bruce A. ; Darley-Usmar, Victor M. / Biological aspects of reactive nitrogen species. In: Biochimica et Biophysica Acta - Bioenergetics. 1999 ; Vol. 1411, No. 2-3. pp. 385-400.
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