Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis

A case control study

J. H. Ramírez, B. Parra, S. Gutierrez, Roger Mauricio Arce Munoz, A. Jaramillo, Y. Ariza, Adolfo Contreras

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the endothelial function, systemic inflammatory biomarkers and subgingival microbial profile associations in patients with and without periodontal disease. Methods: Forty-four patients, half with chronic moderate to severe periodontitis (cases) and half gingivitis and incipient periodontitis (controls) were recruited. Anthropometric, clinical, biochemical parameters, endothelial function, subgingival microbiota, and eight plasma biomarkers of cardiovascular disease were assessed in both groups. Results: Both groups were comparable in anthropometric parameters, blood pressure, and number of positive metabolic syndrome components. Univariate analyses demonstrated significantly higher plasma levels of E-selectin (64.5 ± 30.9 vs 43.8 ± 22.2; P = 0.026) and myeloperoxidase (MPO) (103 ± 114.5 vs 49.1 ± 35.6; P = 0.032) in cases than controls. In addition, significantly higher levels of E-selectin, MPO and ICAM-1 were found in periodontitis patients after adjustment by age and waist circumference. Red complex microorganisms were more frequently detected by culture and polymerase chain reaction in patients with severe to moderate periodontitis. Conclusions: Subgingival red complex bacteria and important cardiovascular risk markers were increased in untreated chronic moderate to severe periodontitis cases. Periodontitis seems to be associated with systemic inflammation that could increase the risk of cardiovascular events. The causal relation between periodontal infections and cardiovascular disease requires further research.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalAustralian Dental Journal
Volume59
Issue number1
DOIs
StatePublished - Mar 1 2014

Fingerprint

Chronic Periodontitis
Periodontitis
Case-Control Studies
Cardiovascular Diseases
Biomarkers
E-Selectin
Periodontal Diseases
Peroxidase
Gingivitis
Microbiota
Waist Circumference
Intercellular Adhesion Molecule-1
Blood Pressure
Inflammation
Bacteria
Polymerase Chain Reaction
Infection
Research

Keywords

  • Periodontal
  • atherosclerosis
  • cardiovascular
  • endothelial
  • inflammation

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis : A case control study. / Ramírez, J. H.; Parra, B.; Gutierrez, S.; Arce Munoz, Roger Mauricio; Jaramillo, A.; Ariza, Y.; Contreras, Adolfo.

In: Australian Dental Journal, Vol. 59, No. 1, 01.03.2014, p. 29-36.

Research output: Contribution to journalArticle

Ramírez, J. H. ; Parra, B. ; Gutierrez, S. ; Arce Munoz, Roger Mauricio ; Jaramillo, A. ; Ariza, Y. ; Contreras, Adolfo. / Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis : A case control study. In: Australian Dental Journal. 2014 ; Vol. 59, No. 1. pp. 29-36.
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