Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

Wei Zhang, Xiao Juan Luo, Li Na Niu, Hong Ye Yang, Cynthia K.Y. Yiu, Tian Da Wang, Li Qun Zhou, Jing Mao, Cui Huang, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

Original languageEnglish (US)
Article number11199
JournalScientific Reports
Volume5
DOIs
StatePublished - Jun 8 2015

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Tooth Remineralization
Biomimetics
Silicon Dioxide
Nanoparticles
Amines
Collagen
Bone and Bones
amorphous calcium phosphate

ASJC Scopus subject areas

  • General

Cite this

Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers. / Zhang, Wei; Luo, Xiao Juan; Niu, Li Na; Yang, Hong Ye; Yiu, Cynthia K.Y.; Wang, Tian Da; Zhou, Li Qun; Mao, Jing; Huang, Cui; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Scientific Reports, Vol. 5, 11199, 08.06.2015.

Research output: Contribution to journalArticle

Zhang, W, Luo, XJ, Niu, LN, Yang, HY, Yiu, CKY, Wang, TD, Zhou, LQ, Mao, J, Huang, C, Pashley, DH & Tay, FCM 2015, 'Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers', Scientific Reports, vol. 5, 11199. https://doi.org/10.1038/srep11199
Zhang, Wei ; Luo, Xiao Juan ; Niu, Li Na ; Yang, Hong Ye ; Yiu, Cynthia K.Y. ; Wang, Tian Da ; Zhou, Li Qun ; Mao, Jing ; Huang, Cui ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers. In: Scientific Reports. 2015 ; Vol. 5.
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