Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

Wei Zhang, Xiao Juan Luo, Li Na Niu, Hong Ye Yang, Cynthia K.Y. Yiu, Tian Da Wang, Li Qun Zhou, Jing Mao, Cui Huang, David Henry Pashley, Franklin Chi Meng Tay

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23 Scopus citations

Abstract

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

Original languageEnglish (US)
Article number11199
JournalScientific reports
Volume5
DOIs
StatePublished - Jun 8 2015

ASJC Scopus subject areas

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    Zhang, W., Luo, X. J., Niu, L. N., Yang, H. Y., Yiu, C. K. Y., Wang, T. D., Zhou, L. Q., Mao, J., Huang, C., Pashley, D. H., & Tay, F. C. M. (2015). Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers. Scientific reports, 5, [11199]. https://doi.org/10.1038/srep11199