Biomimetic remineralization of dentin

Li Na Niu, Wei Zhang, David Henry Pashley, Lorenzo Breschi, Jing Mao, Ji Hua Chen, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Objectives Remineralization of demineralized dentin is important for improving dentin bonding stability and controlling primary and secondary caries. Nevertheless, conventional dentin remineralization strategy is not suitable for remineralizing completely demineralized dentin within hybrid layers created by etch-and-rinse and moderately aggressive self-etch adhesive systems, or the superficial part of a caries-affected dentin lesion left behind after minimally invasive caries removal. Biomimetic remineralization represents a different approach to this problem by attempting to backfill the demineralized dentin collagen with liquid-like amorphous calcium phosphate nanoprecursor particles that are stabilized by biomimetic analogs of noncollagenous proteins. Methods This paper reviewed the changing concepts in calcium phosphate mineralization of fibrillar collagen, including the recently discovered, non-classical particle-based crystallization concept, formation of polymer-induced liquid-precursors (PILP), experimental collagen models for mineralization, and the need for using phosphate-containing biomimetic analogs for biomimetic mineralization of collagen. Published work on the remineralization of resin-dentin bonds and artificial caries-like lesions by various research groups was then reviewed. Finally, the problems and progress associated with the translation of a scientifically sound concept into a clinically applicable approach are discussed. Results and significance The particle-based biomimetic remineralization strategy based on the PILP process demonstrates great potential in remineralizing faulty hybrid layers or caries-like dentin. Based on this concept, research in the development of more clinically feasible dentin remineralization strategy, such as incorporating poly(anionic) acid-stabilized amorphous calcium phosphate nanoprecursor-containing mesoporous silica nanofillers in dentin adhesives, may provide a promising strategy for increasing of the durability of resin-dentin bonding and remineralizing caries-affected dentin.

Original languageEnglish (US)
Pages (from-to)77-96
Number of pages20
JournalDental Materials
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Biomimetics
Dentin
Collagen
Calcium phosphate
Adhesives
Polymers
Liquids
Resins
Fibrillar Collagens
Crystallization
Silicon Dioxide
Phosphates
Durability
Silica
Acoustic waves
Proteins
Concept Formation
Acids
Research
Theoretical Models

Keywords

  • Biomimetic
  • Dentin
  • Mineralization

ASJC Scopus subject areas

  • Materials Science(all)
  • Dentistry(all)
  • Mechanics of Materials

Cite this

Niu, L. N., Zhang, W., Pashley, D. H., Breschi, L., Mao, J., Chen, J. H., & Tay, F. C. M. (2014). Biomimetic remineralization of dentin. Dental Materials, 30(1), 77-96. https://doi.org/10.1016/j.dental.2013.07.013

Biomimetic remineralization of dentin. / Niu, Li Na; Zhang, Wei; Pashley, David Henry; Breschi, Lorenzo; Mao, Jing; Chen, Ji Hua; Tay, Franklin Chi Meng.

In: Dental Materials, Vol. 30, No. 1, 01.01.2014, p. 77-96.

Research output: Contribution to journalArticle

Niu, LN, Zhang, W, Pashley, DH, Breschi, L, Mao, J, Chen, JH & Tay, FCM 2014, 'Biomimetic remineralization of dentin', Dental Materials, vol. 30, no. 1, pp. 77-96. https://doi.org/10.1016/j.dental.2013.07.013
Niu LN, Zhang W, Pashley DH, Breschi L, Mao J, Chen JH et al. Biomimetic remineralization of dentin. Dental Materials. 2014 Jan 1;30(1):77-96. https://doi.org/10.1016/j.dental.2013.07.013
Niu, Li Na ; Zhang, Wei ; Pashley, David Henry ; Breschi, Lorenzo ; Mao, Jing ; Chen, Ji Hua ; Tay, Franklin Chi Meng. / Biomimetic remineralization of dentin. In: Dental Materials. 2014 ; Vol. 30, No. 1. pp. 77-96.
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