Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers

James E. Lockey, Victor L. Roggli, Timothy J. Hilbert, Carol H. Rice, Linda S. Levin, Eric K. Borton, Paul Williams Biddinger, Grace K. Lemasters

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS: Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS: Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.

Original languageEnglish (US)
Pages (from-to)781-788
Number of pages8
JournalJournal of Occupational and Environmental Medicine
Volume54
Issue number7
DOIs
StatePublished - Jul 1 2012

Fingerprint

Ceramics
Lung
Odds Ratio
Confidence Intervals
Asbestos
Thorax

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. / Lockey, James E.; Roggli, Victor L.; Hilbert, Timothy J.; Rice, Carol H.; Levin, Linda S.; Borton, Eric K.; Biddinger, Paul Williams; Lemasters, Grace K.

In: Journal of Occupational and Environmental Medicine, Vol. 54, No. 7, 01.07.2012, p. 781-788.

Research output: Contribution to journalArticle

Lockey, James E. ; Roggli, Victor L. ; Hilbert, Timothy J. ; Rice, Carol H. ; Levin, Linda S. ; Borton, Eric K. ; Biddinger, Paul Williams ; Lemasters, Grace K. / Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. In: Journal of Occupational and Environmental Medicine. 2012 ; Vol. 54, No. 7. pp. 781-788.
@article{d67b4091c27c4b68b5efa86521507124,
title = "Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers",
abstract = "OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS: Within lung tissue, RCF comprised 14{\%} to 100{\%} of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5{\%} (odds ratio, 7.2; 95{\%} confidence interval, 1.4 to 36.8) and 11.6{\%} (odds ratio, 10.3; 95{\%} confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS: Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.",
author = "Lockey, {James E.} and Roggli, {Victor L.} and Hilbert, {Timothy J.} and Rice, {Carol H.} and Levin, {Linda S.} and Borton, {Eric K.} and Biddinger, {Paul Williams} and Lemasters, {Grace K.}",
year = "2012",
month = "7",
day = "1",
doi = "10.1097/JOM.0b013e31825296fd",
language = "English (US)",
volume = "54",
pages = "781--788",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers

AU - Lockey, James E.

AU - Roggli, Victor L.

AU - Hilbert, Timothy J.

AU - Rice, Carol H.

AU - Levin, Linda S.

AU - Borton, Eric K.

AU - Biddinger, Paul Williams

AU - Lemasters, Grace K.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS: Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS: Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.

AB - OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS: Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS: Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.

UR - http://www.scopus.com/inward/record.url?scp=84861747826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861747826&partnerID=8YFLogxK

U2 - 10.1097/JOM.0b013e31825296fd

DO - 10.1097/JOM.0b013e31825296fd

M3 - Article

VL - 54

SP - 781

EP - 788

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 7

ER -