Biphenotypic acute leukaemia: A case series

Ahmed Aribi, Carlos Bueso-Ramos, Eli Estey, Zeev Estrov, Susan O'Brien, Francis Giles, Stefan Faderl, Deborah Thomas, Partow Kebriaei, Guillermo Garcia-Manero, Sherry Pierce, Jorge Cortes, Hagop Kantarjian, Farhad Ravandi

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Biphenotypic acute leukaemia (BAL) is a rare type of leukaemia. Whether patients with BAL should be treated with regimens designed for acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL) or both remain unclear. We have reviewed the clinical data for 31 BAL patients. Most patients co-expressed B-lymphoid and myeloid markers. No specific chromosomal abnormality was identified. The majority of the patients were treated with regimens devised for treating ALL. Seven patients were treated with regimens designed for AML. Complete remission (CR) rates of 78% and 57% were noted respectively. The overall survival probability at 2 years was 60%.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalBritish Journal of Haematology
Volume138
Issue number2
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Keywords

  • Biphenotypic acute leukaemia
  • Diagnosis
  • Immnuophenotype
  • Prognosis
  • Therapy

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Aribi, A., Bueso-Ramos, C., Estey, E., Estrov, Z., O'Brien, S., Giles, F., Faderl, S., Thomas, D., Kebriaei, P., Garcia-Manero, G., Pierce, S., Cortes, J., Kantarjian, H., & Ravandi, F. (2007). Biphenotypic acute leukaemia: A case series. British Journal of Haematology, 138(2), 213-216. https://doi.org/10.1111/j.1365-2141.2007.06634.x