TY - JOUR
T1 - Blood flow and uptake of glucose and amino acids in ischemic muscle
AU - Carroll, James E.
AU - Kaiser, Kenneth K.
AU - Bondy, Stephen C.
AU - Purdy, Janet L.
N1 - Funding Information:
Supported by NIH Grants NS05584 and NS09603 and Foundation's Fund for Research in Psychiatry, Grant 70-487. S.C.B. is recipient of an NIMH Research Scientist Award K05-MH-00102. Address all correspondence to: Dr. James E. Carroll, Washington University School of Medicine, Department of Neurology, 660 South Euclid, Box 8111, St. Louis, Mo. 63110, U.S.A.
PY - 1977/8
Y1 - 1977/8
N2 - In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.
AB - In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [14C]α-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.
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U2 - 10.1016/0022-510X(77)90189-7
DO - 10.1016/0022-510X(77)90189-7
M3 - Article
C2 - 903779
AN - SCOPUS:0017683369
SN - 0022-510X
VL - 33
SP - 155
EP - 160
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -