Body composition of lean and obese Zucker rats in parabiosis

Ruth Babette Harris, E. Hervey, G. R. Hervey, G. Tobin

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Parabiosis is the surgical union of two animals to produce a chronic blood exchange. This model has previously been used to demonstrate the involvement of a blood-borne factor in the feedback control of food intake and regulation of energy balance. It has been hypothesized that obese rats produce a humoral agent that acts centrally to inhibit food intake and accumulation of fat. In this study 50-day-old male or female Zucker rats were joined in either lean-lean pairs or lean-obese pairs. They ate ad libitum until 152 days of age when body composition was determined. Parabiosis inhibited growth in all rats compared with single controls. Lean partners of obese rats had reduced carcass weights, the same percent body protein but less fat than members of lean-lean pairs. Female rats showed larger changes in body composition than did males. These results suggest that obese Zucker rats produce the hypothesized regulatory signal but do not respond to it.

Original languageEnglish (US)
Pages (from-to)275-283
Number of pages9
JournalInternational Journal of Obesity
Volume11
Issue number3
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Parabiosis
Zucker Rats
Body Composition
body composition
rats
Fats
Appetite Regulation
food intake
food law
Eating
blood
body protein
lipids
carcass weight
Weights and Measures
energy balance
Growth
Proteins

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Body composition of lean and obese Zucker rats in parabiosis. / Harris, Ruth Babette; Hervey, E.; Hervey, G. R.; Tobin, G.

In: International Journal of Obesity, Vol. 11, No. 3, 01.01.1987, p. 275-283.

Research output: Contribution to journalArticle

Harris, RB, Hervey, E, Hervey, GR & Tobin, G 1987, 'Body composition of lean and obese Zucker rats in parabiosis', International Journal of Obesity, vol. 11, no. 3, pp. 275-283.
Harris, Ruth Babette ; Hervey, E. ; Hervey, G. R. ; Tobin, G. / Body composition of lean and obese Zucker rats in parabiosis. In: International Journal of Obesity. 1987 ; Vol. 11, No. 3. pp. 275-283.
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