Body mass index and brain structure in healthy children and adolescents

Michael L. Alosco, Kelly M Stanek, Rachel Galioto, Mayuresh S. Korgaonkar, Stuart M. Grieve, Adam M. Brickman, Mary Beth Spitznagel, John Gunstad

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Obesity is associated with cognitive dysfunction in children and adolescents, although the mechanisms underlying these deficits remain unclear. This study examined the associations between body mass index (BMI) and regional gray matter volume and white matter integrity in 120 healthy children and adolescents (6-18 years of age) who underwent magnetic resonance and diffusion tensor imaging. Bonferroni-corrected partial correlation analyses controlling for demographic and clinical characteristics revealed significant inverse associations between demographically standardized BMI values and gray matter volume of frontal (r = -0.31) and limbic (r = -0.35) brain regions. No such pattern emerged for fractional anisotropy of white matter tracts. Subsequent hierarchical regression analyses indicated that the relationship between standardized BMI and structural gray and white matter brain indices did not vary with age. These findings suggest that obesity in children and adolescents is associated with decreased volume of frontal and limbic cerebral gray matter regions. Further research is much needed to better elucidate possible brain-based mechanisms for cognitive dysfunction associated with obesity.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalInternational Journal of Neuroscience
Volume124
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Body Mass Index
Pediatric Obesity
Brain
Obesity
Diffusion Tensor Imaging
Anisotropy
Magnetic Resonance Spectroscopy
Regression Analysis
Demography
Gray Matter
Research
White Matter
Cognitive Dysfunction

Keywords

  • Adolescents
  • BMI
  • Children
  • DTI
  • MRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alosco, M. L., Stanek, K. M., Galioto, R., Korgaonkar, M. S., Grieve, S. M., Brickman, A. M., ... Gunstad, J. (2014). Body mass index and brain structure in healthy children and adolescents. International Journal of Neuroscience, 124(1), 49-55. https://doi.org/10.3109/00207454.2013.817408

Body mass index and brain structure in healthy children and adolescents. / Alosco, Michael L.; Stanek, Kelly M; Galioto, Rachel; Korgaonkar, Mayuresh S.; Grieve, Stuart M.; Brickman, Adam M.; Spitznagel, Mary Beth; Gunstad, John.

In: International Journal of Neuroscience, Vol. 124, No. 1, 01.01.2014, p. 49-55.

Research output: Contribution to journalArticle

Alosco, ML, Stanek, KM, Galioto, R, Korgaonkar, MS, Grieve, SM, Brickman, AM, Spitznagel, MB & Gunstad, J 2014, 'Body mass index and brain structure in healthy children and adolescents', International Journal of Neuroscience, vol. 124, no. 1, pp. 49-55. https://doi.org/10.3109/00207454.2013.817408
Alosco, Michael L. ; Stanek, Kelly M ; Galioto, Rachel ; Korgaonkar, Mayuresh S. ; Grieve, Stuart M. ; Brickman, Adam M. ; Spitznagel, Mary Beth ; Gunstad, John. / Body mass index and brain structure in healthy children and adolescents. In: International Journal of Neuroscience. 2014 ; Vol. 124, No. 1. pp. 49-55.
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