Bone mineral density and turnover in non-corticosteroid treated African American children with juvenile rheumatoid arthritis

Andrew J. Head, Linda K. Myers, Mitchell A. Watsky, Mark W. Greenwell, Karen D. Barrow, Jean A. Michelson, Laura D. Carbone

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective. To determine bone mineral content (BMC), bone mineral density (BMD), Z scores, and markers of bone turnover in African American children with juvenile rheumatoid arthritis (JRA). Methods. Eight children with JRA with no prior exposure to corticosteroids were evaluated. Lumbar spine (L1-L4) and total body and total hip BMC and BMD were determined using dual x-ray absorptiometry (DXA), and Z scores (BMD) were calculated. Serum samples and markers of bone turnover including pyridinoline (PYR), N-terminal propeptide of type 1 procollagen (PLNP), osteocalcin (OC), and bone-specific alkaline phosphatase (BSAP) were measured. Results. The mean Z score (BMD) at the lumbar spine (L1-L4) in patients with JRA was -1.2 ± 0.8. Z scores for total body and total hip were within 1 standard deviation of normal compared with healthy historical controls matched for age, sex, and race. Conclusion. BMD was normal for chronological age (defined as Z score ≥ 2.0) in African American children with JRA who had not previously been treated with corticosteroids. Further studies are needed on the effects of JRA on skeletal health in African American children.

Original languageEnglish (US)
Pages (from-to)1001-1003
Number of pages3
JournalJournal of Rheumatology
Volume33
Issue number5
StatePublished - May 1 2006
Externally publishedYes

Keywords

  • African American
  • Biomarkers
  • Dual X-ray absorptiometry
  • Juvenile rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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