Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction

Ulf M E Wikesjö, Yi Hao Huang, Giuseppe Polimeni, Mohammed Qahash

Research output: Contribution to journalReview article

31 Scopus citations


Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.

Original languageEnglish (US)
Pages (from-to)535-551
Number of pages17
JournalOral and Maxillofacial Surgery Clinics of North America
Issue number4
StatePublished - Nov 1 2007


ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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