TY - JOUR
T1 - Bone Morphogenetic Proteins
T2 - A Realistic Alternative to Bone Grafting for Alveolar Reconstruction
AU - Wikesjö, Ulf M E
AU - Huang, Yi Hao
AU - Polimeni, Giuseppe
AU - Qahash, Mohammed
N1 - Funding Information:
Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. The Laboratory for Applied Periodontal & Craniofacial Regeneration is supported in part by a grant from Nobel Biocare AB, Sweden.
PY - 2007/11
Y1 - 2007/11
N2 - Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.
AB - Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.
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U2 - 10.1016/j.coms.2007.07.004
DO - 10.1016/j.coms.2007.07.004
M3 - Review article
C2 - 18088904
AN - SCOPUS:35348882656
SN - 1042-3699
VL - 19
SP - 535
EP - 551
JO - Oral and Maxillofacial Surgery Clinics of North America
JF - Oral and Maxillofacial Surgery Clinics of North America
IS - 4
ER -