Bone morphogenetic proteins and diabetic retinopathy

Khaled Elmasry, Samar Habib, Mohamed Moustafa, Mohamed Al-Shabrawey

Research output: Contribution to journalReview articlepeer-review

Abstract

Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiovascular complications of diabetes mellitus. However, their particular role in the pathogenesis of microvascular dysfunction associated with diabetic retinopathy (DR) is still under-investigated. Accumulated evidence from our and others’ studies suggests the involvement of BMP signaling in retinal inflammation, hyperpermeability and pathological neovascularization in DR and age-related macular degeneration (AMD). Therefore, targeting BMP signaling in diabetes is proposed as a potential therapeutic strategy to halt the development of microvascular dysfunction in retinal diseases, particularly in DR. The goal of this review article is to discuss the biological functions of BMPs, their underlying mechanisms and their potential role in the pathogenesis of DR in particular.

Original languageEnglish (US)
Article number593
JournalBiomolecules
Volume11
Issue number4
DOIs
StatePublished - 2021

Keywords

  • Age-related macular degeneration
  • BMP2
  • BMP4
  • Bone morphognetic proteins
  • Diabetic retinopathy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Bone morphogenetic proteins and diabetic retinopathy'. Together they form a unique fingerprint.

Cite this