Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - Clinical implications

U. M E Wikesjö, M. Qahash, Y. H. Huang, A. Xiropaidis, G. Polimeni, C. Susin

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Surgical placement of endosseous oral implants is governed by the prosthetic design and by the morphology and quality of the alveolar bone. Nevertheless, often implant placement may be complexed, if at all possible, by alveolar ridge irregularities resulting from periodontal disease, and chronic and acute trauma. In consequence, implant positioning commonly necessitates bone augmentation procedures. One objective of our laboratory is to evaluate the biologic potential of bone morphogenetic proteins (BMP) and other candidate biologics, bone biomaterials, and devices for alveolar ridge augmentation and implant fixation using discriminating large animal models. This focused review illustrates the unique biologic potential, the clinical relevance and perspectives of recombinant human BMP-2 (rhBMP-2) using a variety of carrier technologies to induce local bone formation and implant osseointegration for inlay and onlay indications. Our studies demonstrate a clinically relevant potential of a purpose-designed titanium porous oxide implant surface as stand-alone technology to deliver rhBMP-2 for alveolar augmentation. In perspective, merits and shortcomings of current treatment protocol including bone biomaterials and guided bone regeneration are addressed and explained. We demonstrate that rhBMP-2 has unparalleled potential to augment alveolar bone, and support implant osseointegration and long-term functional loading. Inclusion of rhBMP-2 for alveolar augmentation and osseointegration will not only enhance predictability of existing clinical protocol but also radically change current treatment paradigms.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalOrthodontics and Craniofacial Research
Volume12
Issue number3
DOIs
StatePublished - Aug 1 2009

Fingerprint

Bone Morphogenetic Proteins
Osseointegration
Bone and Bones
Inlays
Biocompatible Materials
Clinical Protocols
Alveolar Ridge Augmentation
Technology
Alveolar Process
Bone Regeneration
Periodontal Diseases
Biological Products
Osteogenesis
Animal Models
Equipment and Supplies
Wounds and Injuries

Keywords

  • Bone formation
  • Bone morphogenetic protein
  • Osseointegration
  • Tissue engineering
  • Titanium implants

ASJC Scopus subject areas

  • Orthodontics
  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - Clinical implications. / Wikesjö, U. M E; Qahash, M.; Huang, Y. H.; Xiropaidis, A.; Polimeni, G.; Susin, C.

In: Orthodontics and Craniofacial Research, Vol. 12, No. 3, 01.08.2009, p. 263-270.

Research output: Contribution to journalReview article

Wikesjö, U. M E ; Qahash, M. ; Huang, Y. H. ; Xiropaidis, A. ; Polimeni, G. ; Susin, C. / Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - Clinical implications. In: Orthodontics and Craniofacial Research. 2009 ; Vol. 12, No. 3. pp. 263-270.
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