Bone reconstruction after surgical treatment of experimental peri-implantitis defects at a sandblasted/acid-etched hydroxyapatite-coated implant: An experimental study in the dog

Hee Namgoong, Myung duck Kim, Young Ku, In Chul Rhyu, Yong Moo Lee, Yang Jo Seol, Hee jin Gu, Cristiano Susin, Ulf Me Wikesjö, Ki Tae Koo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives The objective of this study was to evaluate bone formation/osseointegration following surgical treatment of experimental peri-implantitis at dental implants with different surface characteristics exposed to ligature-induced breakdown conditions. Methods Ten turned (control), 10 sandblasted/acid-etched (SA), and 10 SA/hydroxyapatite nanocoated (HA) implants were installed into the edentulated posterior mandible in five Beagle dogs and allowed to osseointegrate for 12 weeks. Ligature-induced breakdown defects were then induced over 23 weeks using stainless steel wire ligatures. The ligatures were removed and soft tissues were allowed to heal for 3 weeks. Next, exposed implant surfaces were decontaminated followed by guided bone regeneration using a collagen membrane and submerged wound healing. The animals were euthanized for histometric analysis at 12 weeks post-surgery. Results The radiographic analysis showed vertical bone loss following ligature-induced breakdown without statistically significant differences among implant technologies. The histometric analysis showed significantly enhanced bone formation (height) at SA and SA/HA compared with turned implants (p = 0.028) following reconstructive surgery. Bone formation area was greater at SA/HA compared with turned implants, however the difference did not reach statistical significance. Conclusions While ligature-induced defect progression does not appear implant surface dependent in this animal model, bone formation at the decontaminated implant surfaces appears more favourable at SA and SA/HA over turned implants following reconstructive surgery.

Original languageEnglish (US)
Pages (from-to)960-966
Number of pages7
JournalJournal of Clinical Periodontology
Volume42
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

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Experimental Implants
Peri-Implantitis
Durapatite
Ligation
Dogs
Bone and Bones
Acids
Osteogenesis
Reconstructive Surgical Procedures
Osseointegration
Bone Regeneration
Dental Implants
Stainless Steel
Mandible
Wound Healing
Collagen
Animal Models
Technology
Membranes

Keywords

  • acid-etched surface
  • animal study
  • dental implants
  • guided bone regeneration
  • hydroxyapatite
  • ligature-induced breakdown

ASJC Scopus subject areas

  • Periodontics

Cite this

Bone reconstruction after surgical treatment of experimental peri-implantitis defects at a sandblasted/acid-etched hydroxyapatite-coated implant : An experimental study in the dog. / Namgoong, Hee; Kim, Myung duck; Ku, Young; Rhyu, In Chul; Lee, Yong Moo; Seol, Yang Jo; Gu, Hee jin; Susin, Cristiano; Wikesjö, Ulf Me; Koo, Ki Tae.

In: Journal of Clinical Periodontology, Vol. 42, No. 10, 01.10.2015, p. 960-966.

Research output: Contribution to journalArticle

Namgoong, Hee ; Kim, Myung duck ; Ku, Young ; Rhyu, In Chul ; Lee, Yong Moo ; Seol, Yang Jo ; Gu, Hee jin ; Susin, Cristiano ; Wikesjö, Ulf Me ; Koo, Ki Tae. / Bone reconstruction after surgical treatment of experimental peri-implantitis defects at a sandblasted/acid-etched hydroxyapatite-coated implant : An experimental study in the dog. In: Journal of Clinical Periodontology. 2015 ; Vol. 42, No. 10. pp. 960-966.
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abstract = "Objectives The objective of this study was to evaluate bone formation/osseointegration following surgical treatment of experimental peri-implantitis at dental implants with different surface characteristics exposed to ligature-induced breakdown conditions. Methods Ten turned (control), 10 sandblasted/acid-etched (SA), and 10 SA/hydroxyapatite nanocoated (HA) implants were installed into the edentulated posterior mandible in five Beagle dogs and allowed to osseointegrate for 12 weeks. Ligature-induced breakdown defects were then induced over 23 weeks using stainless steel wire ligatures. The ligatures were removed and soft tissues were allowed to heal for 3 weeks. Next, exposed implant surfaces were decontaminated followed by guided bone regeneration using a collagen membrane and submerged wound healing. The animals were euthanized for histometric analysis at 12 weeks post-surgery. Results The radiographic analysis showed vertical bone loss following ligature-induced breakdown without statistically significant differences among implant technologies. The histometric analysis showed significantly enhanced bone formation (height) at SA and SA/HA compared with turned implants (p = 0.028) following reconstructive surgery. Bone formation area was greater at SA/HA compared with turned implants, however the difference did not reach statistical significance. Conclusions While ligature-induced defect progression does not appear implant surface dependent in this animal model, bone formation at the decontaminated implant surfaces appears more favourable at SA and SA/HA over turned implants following reconstructive surgery.",
keywords = "acid-etched surface, animal study, dental implants, guided bone regeneration, hydroxyapatite, ligature-induced breakdown",
author = "Hee Namgoong and Kim, {Myung duck} and Young Ku and Rhyu, {In Chul} and Lee, {Yong Moo} and Seol, {Yang Jo} and Gu, {Hee jin} and Cristiano Susin and Wikesj{\"o}, {Ulf Me} and Koo, {Ki Tae}",
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T2 - An experimental study in the dog

AU - Namgoong, Hee

AU - Kim, Myung duck

AU - Ku, Young

AU - Rhyu, In Chul

AU - Lee, Yong Moo

AU - Seol, Yang Jo

AU - Gu, Hee jin

AU - Susin, Cristiano

AU - Wikesjö, Ulf Me

AU - Koo, Ki Tae

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objectives The objective of this study was to evaluate bone formation/osseointegration following surgical treatment of experimental peri-implantitis at dental implants with different surface characteristics exposed to ligature-induced breakdown conditions. Methods Ten turned (control), 10 sandblasted/acid-etched (SA), and 10 SA/hydroxyapatite nanocoated (HA) implants were installed into the edentulated posterior mandible in five Beagle dogs and allowed to osseointegrate for 12 weeks. Ligature-induced breakdown defects were then induced over 23 weeks using stainless steel wire ligatures. The ligatures were removed and soft tissues were allowed to heal for 3 weeks. Next, exposed implant surfaces were decontaminated followed by guided bone regeneration using a collagen membrane and submerged wound healing. The animals were euthanized for histometric analysis at 12 weeks post-surgery. Results The radiographic analysis showed vertical bone loss following ligature-induced breakdown without statistically significant differences among implant technologies. The histometric analysis showed significantly enhanced bone formation (height) at SA and SA/HA compared with turned implants (p = 0.028) following reconstructive surgery. Bone formation area was greater at SA/HA compared with turned implants, however the difference did not reach statistical significance. Conclusions While ligature-induced defect progression does not appear implant surface dependent in this animal model, bone formation at the decontaminated implant surfaces appears more favourable at SA and SA/HA over turned implants following reconstructive surgery.

AB - Objectives The objective of this study was to evaluate bone formation/osseointegration following surgical treatment of experimental peri-implantitis at dental implants with different surface characteristics exposed to ligature-induced breakdown conditions. Methods Ten turned (control), 10 sandblasted/acid-etched (SA), and 10 SA/hydroxyapatite nanocoated (HA) implants were installed into the edentulated posterior mandible in five Beagle dogs and allowed to osseointegrate for 12 weeks. Ligature-induced breakdown defects were then induced over 23 weeks using stainless steel wire ligatures. The ligatures were removed and soft tissues were allowed to heal for 3 weeks. Next, exposed implant surfaces were decontaminated followed by guided bone regeneration using a collagen membrane and submerged wound healing. The animals were euthanized for histometric analysis at 12 weeks post-surgery. Results The radiographic analysis showed vertical bone loss following ligature-induced breakdown without statistically significant differences among implant technologies. The histometric analysis showed significantly enhanced bone formation (height) at SA and SA/HA compared with turned implants (p = 0.028) following reconstructive surgery. Bone formation area was greater at SA/HA compared with turned implants, however the difference did not reach statistical significance. Conclusions While ligature-induced defect progression does not appear implant surface dependent in this animal model, bone formation at the decontaminated implant surfaces appears more favourable at SA and SA/HA over turned implants following reconstructive surgery.

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