Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible

Lucy K. Nagashima, Michelle Rondon-Newby, Ibrahim E. Zakhary, William W. Nagy, Uriel Zapata, Paul C. Dechow, Lynne A. Opperman, Mohammed E. Elsalanty

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: Bone transport distraction osteogenesis provides a promising alternative to traditional grafting techniques. However, existing bone transport distraction osteogenesis devices have many limitations. The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone. Materials and Methods: Eleven adult foxhounds were divided into an unreconstructed control group of 5 animals and an experimental group of 6 animals. In each animal, a 34-mm segmental defect was created in the mandible. The defect was reconstructed with a bone transport reconstruction plate. Histologic and biomechanical characteristics of the regenerate and unrepaired defect were analyzed and compared with bone on the contralateral side of the mandible after 4 weeks of consolidation. Results: The reconstructed defect was bridged with new bone, with little bone in the control defect. Regenerate density and microhardness were 22.3% and 42.6%, respectively, lower than the contralateral normal bone. Likewise, the anisotropy of the experimental group was statistically lower than in the contralateral bone. Half the experimental animals showed nonunion at the docking site. Conclusion: The device was very stable and easy to install and activate. After 1 month of consolidation, the defect was bridged with new bone, with evidence of active bone formation. Regenerate bone was less mature than the control bone. Studies are underway to identify when the regenerate properties compare with normal bone and to identify methods to augment bone union at the docking site.

Original languageEnglish (US)
Pages (from-to)429-439
Number of pages11
JournalJournal of Oral and Maxillofacial Surgery
Volume70
Issue number2
DOIs
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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    Nagashima, L. K., Rondon-Newby, M., Zakhary, I. E., Nagy, W. W., Zapata, U., Dechow, P. C., Opperman, L. A., & Elsalanty, M. E. (2012). Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible. Journal of Oral and Maxillofacial Surgery, 70(2), 429-439. https://doi.org/10.1016/j.joms.2011.02.016