Boron nitride nanotubes included thermally cross-linked gelatin-glucose scaffolds show improved properties

Özlem Şen, Mustafa Culha

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Boron nitride nanotubes (BNNTs) are increasingly investigated for their medical and biomedical applications due to their unique properties such as resistance to oxidation, thermal and electrical insulation, and biocompatibility. BNNTs can be used to enhance mechanical strength of biomedical structures such as scaffolds in tissue engineering applications. In this study, we report the use of BNNTs and hydroxylated BNNTs (BNNT-OH) to improve the properties of gelatin-glucose scaffolds prepared with electrospinning technique. Human dermal fibroblast (HDF) cells are used for the toxicity assessment and cell seeding studies. It is found that the addition of BNNTs into the scaffold does not influence cell viability, decreases the scaffold degradation rate, and improves cell attachment and proliferation compared to only-gelatin scaffold.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume138
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • BNNT-OH
  • Boron nitride nanotubes
  • Cell proliferation
  • Gelatin
  • Mechanical strength
  • Scaffold

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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