Bosutinib for the treatment of chronic myeloid leukemia in chronic phase

A. Quintás-Cardama, H. Kantarjian, Jorge Cortes

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The clinical outcome for patients with chronic myeloid leukemia in chronic phase (CML-CP) is currently very favorable due to the availability of tyrosine kinase inhibitors (TKIs) that are well tolerated and effectively suppress the constitutively activated BCR-ABL1 kinase that underlies the pathogenesis of this malignancy. Three TKIs - imatinib, nilotinib and dasatinib - have been approved as frontline therapy in CML-CP. Another TKI, bosutinib, inhibits with high potency numerous tyrosine kinases, including BCRABL1, Src family of kinases and MAPK, among others. Like nilotinib and dasatinib, bosutinib is a second-generation TKI that inhibits the majority of mutations associated with imatinib resistance, with the exception of T315I. In patients with CML-CP with prior intolerance or resistance to imatinib therapy, bosutinib rendered response rates similar to those observed in the same patient population treated with nilotinib or dasatinib. Preliminary results from the ongoing phase III BELA study in which bosutinib is compared in a randomized fashion to imatinib for patients with newly diagnosed CML-CP have been recently reported. We herein summarize the preclinical and clinical experience of bosutinib in CML.

Original languageEnglish (US)
Pages (from-to)177-188
Number of pages12
JournalDrugs of Today
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • BCR-ABL1
  • Bosutinib
  • Chronic myeloid leukemia
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Bosutinib for the treatment of chronic myeloid leukemia in chronic phase'. Together they form a unique fingerprint.

  • Cite this