Botulinum toxin A during pregnancy

A survey of treating physicians

John Christopher Morgan, S. S. Iyer, E. T. Moser, C. Singer, Kapil Dev Sethi

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Botulinum toxin A (btxA) is widely used for cosmetic purposes, headaches, dystonia, spasticity, pain and other on and off label uses. Despite the widespread use of btxA in women of childbearing potential, there are few data on the effects of this drug on pregnant women and the fetus. The goal of this study was to survey physicians who use btxA, to determine their experience with pregnant women. We surveyed 900 physicians who used commercially available btxA. The questionnaire asked treating physicians if they had knowingly or unknowingly injected pregnant women and what was the outcome of each pregnancy. In total, 396 physicians (44%) returned questionnaires, of whom only 12 physicians reported injecting pregnant women with btxA. Sixteen pregnant women were injected, mostly in the first trimester, and only one patient, who had prior spontaneous abortions, suffered a miscarriage. Another woman had a therapeutic abortion. All other pregnancies went to term and there were no fetal malformations. Based on this limited survey of treating physicians in the USA, btxA appears to be relatively safe for both expectant mother and fetus. We need further data, however, and we would recommend that physicians and patients carefully consider the risks and benefits before using btxA in pregnant women.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Type A Botulinum Toxins
Pregnant Women
Physicians
Pregnancy
Spontaneous Abortion
Fetus
Therapeutic Abortion
Off-Label Use
Dystonia
First Pregnancy Trimester
Pregnancy Outcome
Surveys and Questionnaires
Cosmetics
Headache
Mothers
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Botulinum toxin A during pregnancy : A survey of treating physicians. / Morgan, John Christopher; Iyer, S. S.; Moser, E. T.; Singer, C.; Sethi, Kapil Dev.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 77, No. 1, 01.01.2006, p. 117-119.

Research output: Contribution to journalReview article

Morgan, John Christopher ; Iyer, S. S. ; Moser, E. T. ; Singer, C. ; Sethi, Kapil Dev. / Botulinum toxin A during pregnancy : A survey of treating physicians. In: Journal of Neurology, Neurosurgery and Psychiatry. 2006 ; Vol. 77, No. 1. pp. 117-119.
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