Brain and gut interactions in irritable bowel syndrome

New paradigms and new understandings

Enrique Coss-Adame, Satish Sanku Chander Rao

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Irritable bowel syndrome (IBS) is characterized by abdominal pain and altered bowel habits. Visceral hypersensitivity is believed to be a key underlying mechanism that causes pain. There is evidence that interactions within the brain and gut axis (BGA), that involves both the afferent-ascending and the efferent-descending pathways, as well as the somatosensory cortex, insula, amygdala, anterior cingulate cortex, and hippocampus, are deranged in IBS showing both the activation and inactivation. Clinical manifestations of IBS such as pain, altered gut motility, and psychological dysfunction may each be explained, in part, through the changes in the BGA, but there is conflicting information, and its precise role is not fully understood. A better understanding of the BGA may shed more knowledge regarding the pathophysiology of IBS that in turn may lead to the discovery of novel therapies for this common disorder.

Original languageEnglish (US)
Article number379
JournalCurrent Gastroenterology Reports
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Irritable Bowel Syndrome
Brain
Efferent Pathways
Pain
Somatosensory Cortex
Gyrus Cinguli
Amygdala
Abdominal Pain
Habits
Hippocampus
Hypersensitivity
Psychology
Therapeutics

Keywords

  • Brain-gut axis
  • Cortical-evoked potentials
  • CRF
  • Irritable bowel syndrome
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Brain and gut interactions in irritable bowel syndrome : New paradigms and new understandings. / Coss-Adame, Enrique; Rao, Satish Sanku Chander.

In: Current Gastroenterology Reports, Vol. 16, No. 4, 379, 01.01.2014.

Research output: Contribution to journalArticle

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