Brain Blood Flow Modulates the Neurotoxic Action of Hyperbaric Oxygen via Neuronal and Endothelial Nitric Oxide

A. N. Moskvin, S. Yu Zhilyaev, O. I. Sharapov, T. F. Platonova, Diana Raisovna Gutsaeva, V. B. Kostkin, I. T. Demchenko

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Studies on conscious rats with inhibition of NO synthase were used to assess the dynamics of brain blood flow and EEG traces during hyperbaric oxygenation at 4 or 5 atm. Oxygen at a pressure of 4 atm induced cerebral vasoconstriction in intact animals and decreased blood flow by 11-18% (p < 0.05) during 60-min exposure to hyperbaric oxygenation. Paroxysmal EEG activity and oxygen convulsions did not occur in rats at 4 atm of O2. At 5 atm, convulsive activity appeared on the EEG at 41 ± 1.9 min, and blood flow decreased significantly during the first 20 min; blood flow increased by 23 ± 9%, as compared with controls, (p < 0.01) before the appearance of convulsions on the EEG. Prior inhibition of NO synthase I (NOS I) and NO synthase III (NOS III) with Nω-nitro-L-arginine methyl ester (L-NAME, 30 mg/kg) or inhibition only of NOS I with 7-nitroindazole (7-NI, 50 mg/kg) prevented the development of hyperoxic hyperemia and paroxysmal spikes on the EEG during hyperbaric oxygenation at 5 atm. These results show that hyperbaric oxygen induces changes in cerebral blood flow which modulate its neurotoxic action via nitric oxide synthesized both in neurons and in cerebral vessels.

Original languageEnglish (US)
Pages (from-to)883-888
Number of pages6
JournalNeuroscience and Behavioral Physiology
Volume33
Issue number9
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

Fingerprint

Electroencephalography
Nitric Oxide
Nitric Oxide Synthase
Hyperbaric Oxygenation
Oxygen
Brain
Glycogen Synthase
Cerebrovascular Circulation
Seizures
NG-Nitroarginine Methyl Ester
Hyperemia
Vasoconstriction
Neurons
Pressure

Keywords

  • Cerebral blood flow
  • Hyperbaric oxygenation
  • Nitric oxide
  • Oxygen convulsions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brain Blood Flow Modulates the Neurotoxic Action of Hyperbaric Oxygen via Neuronal and Endothelial Nitric Oxide. / Moskvin, A. N.; Zhilyaev, S. Yu; Sharapov, O. I.; Platonova, T. F.; Gutsaeva, Diana Raisovna; Kostkin, V. B.; Demchenko, I. T.

In: Neuroscience and Behavioral Physiology, Vol. 33, No. 9, 01.11.2003, p. 883-888.

Research output: Contribution to journalArticle

Moskvin, A. N. ; Zhilyaev, S. Yu ; Sharapov, O. I. ; Platonova, T. F. ; Gutsaeva, Diana Raisovna ; Kostkin, V. B. ; Demchenko, I. T. / Brain Blood Flow Modulates the Neurotoxic Action of Hyperbaric Oxygen via Neuronal and Endothelial Nitric Oxide. In: Neuroscience and Behavioral Physiology. 2003 ; Vol. 33, No. 9. pp. 883-888.
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