Brain metastases in N2-positive non-small-cell lung cancer: Implications for prophylactic cranial irradiation

Mollit Bansal, Teresa Boyle, Alex Ehsan, Frank E. Mott

Research output: Contribution to journalArticle


Patients with non-small-cell lung cancer with positive lymph nodes (stage IIIA and IIIB) have an increased risk for brain metastases. Those with nonsquamous histology are at higher risk. Despite this fact, the use of prophylactic cranial irradiation (PCI) has not shown an improvement in survival in these patients and is still considered to be investigational. The Radiation Therapy Oncology Group attempted to prospectively address this in a randomized trial that recently closed because of poor accrual. We present 2 cases and review the literature and provide an argument for the consideration of PCI in select patients.

Original languageEnglish (US)
Pages (from-to)227-229
Number of pages3
JournalClinical Lung Cancer
Issue number4
Publication statusPublished - Jul 2008



  • Chemoradiation
  • Cognitive function
  • Lobectomy
  • Palliation

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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