Breast Cancer Disparities: How Can We Leverage Genomics to Improve Outcomes?

Melissa B Davis, Lisa A. Newman

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Breast cancer mortality rates are higher in African American compared with white American women. Disproportionately rising incidence rates, coupled with higher rates of biologically aggressive disease among African Americans is resulting in a widening of the mortality disparity. Higher rates of triple-negative breast cancer among African American women, as well as women from western sub-Saharan Africa, has prompted questions regarding the role of African ancestry as a marker of hereditary susceptibility for specific disease phenotypes. Advances in germline genetics, as well as somatic tumor genomic research, hold great promise in the effort to understand the biology of breast cancer variations between different population subsets.

Original languageEnglish (US)
Pages (from-to)217-234
Number of pages18
JournalSurgical Oncology Clinics of North America
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Genomics
African Americans
Breast Neoplasms
Triple Negative Breast Neoplasms
Western Africa
Mortality
Africa South of the Sahara
Disease Susceptibility
Phenotype
Incidence
Research
Population
Neoplasms

Keywords

  • African ancestry
  • Disparities
  • Genetics
  • Genomics

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Breast Cancer Disparities : How Can We Leverage Genomics to Improve Outcomes? / Davis, Melissa B; Newman, Lisa A.

In: Surgical Oncology Clinics of North America, Vol. 27, No. 1, 01.01.2018, p. 217-234.

Research output: Contribution to journalReview article

Davis, Melissa B ; Newman, Lisa A. / Breast Cancer Disparities : How Can We Leverage Genomics to Improve Outcomes?. In: Surgical Oncology Clinics of North America. 2018 ; Vol. 27, No. 1. pp. 217-234.
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