Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Hasan Korkaya, Suling Liu, Max S. Wicha

Research output: Contribution to journalReview article

342 Citations (Scopus)

Abstract

Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

Original languageEnglish (US)
Pages (from-to)3804-3809
Number of pages6
JournalJournal of Clinical Investigation
Volume121
Issue number10
DOIs
StatePublished - Oct 3 2011

Fingerprint

Tumor Microenvironment
Neoplastic Stem Cells
Breast Neoplasms
Cytokines
Mesenchymal Stromal Cells
Adipocytes
Intercellular Signaling Peptides and Proteins
Stem Cells
Endothelial Cells
Neoplasm Metastasis
Neoplasms
Therapeutics
Cancer-Associated Fibroblasts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Breast cancer stem cells, cytokine networks, and the tumor microenvironment. / Korkaya, Hasan; Liu, Suling; Wicha, Max S.

In: Journal of Clinical Investigation, Vol. 121, No. 10, 03.10.2011, p. 3804-3809.

Research output: Contribution to journalReview article

@article{e2a91d22d80f429dabaf3d075dfbe670,
title = "Breast cancer stem cells, cytokine networks, and the tumor microenvironment",
abstract = "Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.",
author = "Hasan Korkaya and Suling Liu and Wicha, {Max S.}",
year = "2011",
month = "10",
day = "3",
doi = "10.1172/JCI57099",
language = "English (US)",
volume = "121",
pages = "3804--3809",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "10",

}

TY - JOUR

T1 - Breast cancer stem cells, cytokine networks, and the tumor microenvironment

AU - Korkaya, Hasan

AU - Liu, Suling

AU - Wicha, Max S.

PY - 2011/10/3

Y1 - 2011/10/3

N2 - Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

AB - Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

UR - http://www.scopus.com/inward/record.url?scp=80053401068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053401068&partnerID=8YFLogxK

U2 - 10.1172/JCI57099

DO - 10.1172/JCI57099

M3 - Review article

C2 - 21965337

AN - SCOPUS:80053401068

VL - 121

SP - 3804

EP - 3809

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 10

ER -