Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Hasan Korkaya, Suling Liu, Max S. Wicha

Research output: Contribution to journalReview article

377 Scopus citations

Abstract

Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

Original languageEnglish (US)
Pages (from-to)3804-3809
Number of pages6
JournalJournal of Clinical Investigation
Volume121
Issue number10
DOIs
StatePublished - Oct 3 2011

ASJC Scopus subject areas

  • Medicine(all)

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