Breast conservation therapy for invasive lobular carcinoma: The impact of lobular carcinoma in situ in the surgical specimen on local recurrence and axillary node status

A. J. Stolier, G. Barre, J. S. Bolton, G. M. Fuhrman, Stephen Warwick Looney

Research output: Contribution to journalArticle

16 Scopus citations


Forty patients undergoing breast-conserving therapy for invasive lobular carcinoma were studied for the volume of lobular carcinoma in situ (LCIS) in the surgical specimen and its relationship to the surgical margins. The pathology of all cases was reviewed for margin status as well as the volume of LCIS in the surgical specimen. Mean follow-up time was 67 months. There were no local recurrences despite the fact that 38 per cent of patients had close or involved margins. There was one cancer-related death. Increasing tumor size and moderate or extensive involvement of the surgical specimen with LCIS were found to be independent predictors of axillary node metastases. The volume of LCIS in the surgical did not appear to have an impact on local recurrence. This paper adds to the growing body of literature suggesting that in patients undergoing breast-conserving therapy, LCIS in the surgical margin does not impact the risk of local recurrence and therefore may not require reexcision for close or involved surgical margins.

Original languageEnglish (US)
Pages (from-to)818-821
Number of pages4
JournalAmerican Surgeon
Issue number9
StatePublished - Dec 1 2004
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

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