Brief report: The age-associated decline of androgens in reproductive age and menopausal black and white women

Jessica B. Spencer, Mitchel Klein, Ashim Kumar, Ricardo Azziz

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Context: The effect of race and obesity on the age-associated decline of androgens in reproductive-aged and menopausal women has not been well characterized. Objective: Our objective was to determine the impact of racial differences and body mass index (BMI) on the change in androgen levels during a woman's reproductive and early menopausal years. Design and Setting: We conducted a frequency-matched cross-sectional study at a tertiary academic medical center. Patients or Other Participants: Subjects included 260 healthy, nonhirsute and eumenorrheic, self-identified Black and White women, ages 15-60 yr. Interventions: A medical and reproductive history, physical exam, and blood sampling were determined in the fasting state during the early follicular phase. Main Outcome Measures: Serum levels of androgens or androgen metabolites (dehydroepiandrosterone sulfate, androstenedione, and total and free testosterone) and SHBG were measured and the BMI, the waist-to-hip ratio (WHR), and the basal insulin resistance estimated by the homeostasis model assessment for insulin resistance determined. Results: After controlling for differences in BMI, insulin resistance, and WHR, Black women had lower androgen levels than age-matched White women. All androgens, or androgen metabolites, declined similarly across the reproductive lifespan and menopausal transition in both Black and White women. Race was a significant predictor of dehydroepiandrosterone sulfate, androstenedione, and total and free testosterone but not SHBG. Conclusions: Eumenorrheic, nonhirsute Black women have a lower range of normal androgen levels than White women of the same age, BMI, WHR, and homeostasis model assessment index for insulin resistance. Race and age-adjusted data should be considered when evaluating androgen levels in women between the ages of 15 and 60 yr.

Original languageEnglish (US)
Pages (from-to)4730-4733
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number12
DOIs
StatePublished - Dec 2007

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Androgens
Waist-Hip Ratio
Insulin Resistance
Body Mass Index
Insulin
Dehydroepiandrosterone Sulfate
Androstenedione
Metabolites
Testosterone
Homeostasis
hydroquinone
Reproductive History
Follicular Phase
Fasting
Reference Values
Blood
Obesity
Cross-Sectional Studies
Outcome Assessment (Health Care)
Sampling

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Brief report : The age-associated decline of androgens in reproductive age and menopausal black and white women. / Spencer, Jessica B.; Klein, Mitchel; Kumar, Ashim; Azziz, Ricardo.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 12, 12.2007, p. 4730-4733.

Research output: Contribution to journalArticle

Spencer, Jessica B. ; Klein, Mitchel ; Kumar, Ashim ; Azziz, Ricardo. / Brief report : The age-associated decline of androgens in reproductive age and menopausal black and white women. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 12. pp. 4730-4733.
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