Brominated vegetable oil myopathy: Inhibition at multiple sites

James E. Carroll, Beverly J. Norris, Aida Villadiego, Steve D. Wheeler

Research output: Contribution to journalArticle

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Abstract

Skeletal muscle lipid storage was induced by feeding rats brominated vegetable oil (BVO). The defect was examined by measuring radioactive substrate oxidation, intermediates of fatty acid oxidation, and activities of oxidative enzymes. One‐ and U‐[14C] palmitate and 1‐[14C] pyruvate oxidation were reduced in muscle after four doses of BVO. Inhibition of U‐[14C] palmitate oxidation occurred after two doses. Short chain acylcoenzyme A(CoA) derivatives accumulated in the muscle. Several enzymes of β‐oxidation were significantly reduced, with the greatest reduction in 3‐ketoacyl‐CoA thiolase. The inhibition probably affected multiple sites of CoA and CoA‐derivative metabolism.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalMuscle & Nerve
Volume7
Issue number8
DOIs
StatePublished - Oct 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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