Bub1-mediated adaptation of the spindle checkpoint

Greicy H. Goto, Ashutosh Mishra, Rashid Abdulle, Clive A. Slaughter, Katsumi Kitagawa

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spindles in anaphase, but the mechanisms by which this deactivation and adaptation to prolonged mitotic arrest occur remain obscure. Our results strongly suggest that Cdc28-mediated phosphorylation of Bub1 at T566 plays an important role for the degradation of Bub1 in anaphase, and the phosphorylation is required for adaptation of the spindle checkpoint to prolonged mitotic arrest.

Original languageEnglish (US)
Article numbere1001282
JournalPLoS Genetics
Volume7
Issue number1
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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