Burkitt lymphoma and atypical burkitt or burkitt-like lymphoma: Should these be treated as different diseases?

Deborah A. Thomas, Susan O'Brien, Stefan Faderl, John T. Manning, Jorge Romaguera, Luis Fayad, Fredrick Hagemeister, Jeffrey Medeiros, Jorge Cortes, Hagop Kantarjian

Research output: Contribution to journalArticle

Abstract

Burkitt lymphoma (BL) is a mature B-cell non-Hodgkin lymphoma with an aggressive clinical course. Since the advent of short, intensive, multiagent chemoimmunotherapy regimens, it has carried a favorable prognosis. BL has been rather well characterized, whereas the other lymphomas morphologically resembling it are more heterogeneous. The cases classified as atypical BL/Burkitt-like lymphoma by the 2001 World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissue were thought to represent a continuum between BL and diffuse large B-cell lymphoma (DLBCL). The optimal therapeutic strategy for this provisional entity was not definitively established. However, recent incorporation of molecular genetic data into the 2008 WHO Classification has allowed further refinements with significant therapeutic implications, including the designation of a new provisional entity, "B-cell lymphoma, unclassifiable, with features intermediate between BL and DLBCL." This review presents a comprehensive overview of the previously designated provisional entity of atypical BL/BLL in conjunction with a detailed comparison with BL and DLBCL.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalCurrent Hematologic Malignancy Reports
Volume6
Issue number1
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Fingerprint

Burkitt Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Lymphoid Tissue
Non-Hodgkin's Lymphoma
Molecular Biology
Lymphoma
Therapeutics

Keywords

  • Atypical Burkitt
  • Burkitt
  • Burkitt-like
  • c-myc
  • DLBCL
  • Non-Hodgkin lymphoma
  • Therapy
  • WHO classification

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Burkitt lymphoma and atypical burkitt or burkitt-like lymphoma : Should these be treated as different diseases? / Thomas, Deborah A.; O'Brien, Susan; Faderl, Stefan; Manning, John T.; Romaguera, Jorge; Fayad, Luis; Hagemeister, Fredrick; Medeiros, Jeffrey; Cortes, Jorge; Kantarjian, Hagop.

In: Current Hematologic Malignancy Reports, Vol. 6, No. 1, 01.03.2011, p. 58-66.

Research output: Contribution to journalArticle

Thomas, DA, O'Brien, S, Faderl, S, Manning, JT, Romaguera, J, Fayad, L, Hagemeister, F, Medeiros, J, Cortes, J & Kantarjian, H 2011, 'Burkitt lymphoma and atypical burkitt or burkitt-like lymphoma: Should these be treated as different diseases?', Current Hematologic Malignancy Reports, vol. 6, no. 1, pp. 58-66. https://doi.org/10.1007/s11899-010-0076-4
Thomas, Deborah A. ; O'Brien, Susan ; Faderl, Stefan ; Manning, John T. ; Romaguera, Jorge ; Fayad, Luis ; Hagemeister, Fredrick ; Medeiros, Jeffrey ; Cortes, Jorge ; Kantarjian, Hagop. / Burkitt lymphoma and atypical burkitt or burkitt-like lymphoma : Should these be treated as different diseases?. In: Current Hematologic Malignancy Reports. 2011 ; Vol. 6, No. 1. pp. 58-66.
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