Butenafine 1% cream in the treatment of tinea cruris

A multicenter, vehicle-controlled, double-blind trial

Jack L Lesher, D. E. Babel, D. M. Stewart, T. M. Jones, L. Kaminester, M. Goldman, J. S. Weintraub

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Butenafine hydrochloride, a potent antifungal agent related to the allylamines, has been used in Japan for treating various cutaneous mycoses including tinea cruris.Objective: We compared the safety and efficacy of butenafine hydrochloride and its vehicle when used once daily for 2 weeks to treat tinea cruris. Methods: Patients (n = 93) with tinea cruris and a positive potassium hydroxide examination and mycologic culture were enrolled. Of the 76 patients assessed for efficacy, 37 applied butenafine and 39 applied vehicle once daily for 2 weeks. Assessments were made at the end of the 2-week treatment period and 4 weeks after the end of treatment. Results: Patients in the butenafine group had a higher mycologic cure rate by day 7 (66% vs 13%, p < 0.0001), with marked improvement 4 weeks after the end of treatment (81% vs 13%, p < 0.0001). They also had a higher rate of effective treatment at day 7 (29% vs 5%, p < 0.01) and at 4 weeks after treatment (73% vs 5%, < 0.0001). Adverse events definitely related to butenafine treatment were limited to one case of burning sensation after application. Conclusion: Butenafine applied once daily for 2 weeks is effective in treating tinea cruris. The proportion of patients cured increased between the end of treatment and 4 weeks after treatment.

Original languageEnglish (US)
JournalJournal of the American Academy of Dermatology
Volume36
Issue number2
DOIs
StatePublished - Feb 25 1997

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Tinea
Therapeutics
Allylamine
butenafine
Mycoses
Antifungal Agents
Japan
Safety
Skin

ASJC Scopus subject areas

  • Dermatology

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Butenafine 1% cream in the treatment of tinea cruris : A multicenter, vehicle-controlled, double-blind trial. / Lesher, Jack L; Babel, D. E.; Stewart, D. M.; Jones, T. M.; Kaminester, L.; Goldman, M.; Weintraub, J. S.

In: Journal of the American Academy of Dermatology, Vol. 36, No. 2, 25.02.1997.

Research output: Contribution to journalArticle

Lesher, Jack L ; Babel, D. E. ; Stewart, D. M. ; Jones, T. M. ; Kaminester, L. ; Goldman, M. ; Weintraub, J. S. / Butenafine 1% cream in the treatment of tinea cruris : A multicenter, vehicle-controlled, double-blind trial. In: Journal of the American Academy of Dermatology. 1997 ; Vol. 36, No. 2.
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