C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome

Anne S. Tsao, Hagop Kantarjian, Deborah Thomas, Francis Giles, Jorge Cortes, Guillermo Garcia-Manero, Yang Huh, Ying Yang, Yu Shen, Maher Albitar, Elihu Estey

Research output: Contribution to journalArticle

Abstract

We hypothesize that c-kit expression may be associated with disease-specific features and have prognostic value in acute leukemias. In acute lymphocytic leukemia (ALL), higher levels of c-kit expression predicted lower complete response (CR) rates, suggesting that these patients may benefit from acute myelogenous leukemia (AML) therapy. Despite a negative association with the Philadelphia-chromosome, there was no correlation with disease-free survival (DFS) in CR. In AML, c-kit was associated with older age and cytogenetic abnormality t(-5, -7). Consequently higher levels of c-kit predicted lower CR rates. However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalLeukemia Research
Volume28
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

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Acute Myeloid Leukemia
Disease-Free Survival
Leukemia
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromosome Aberrations
Multivariate Analysis
Therapeutics

Keywords

  • Acute lymphocytic leukemia (ALL)
  • Acute myelogenous leukemia (AML)
  • C-kit
  • Martingale residual plots

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome. / Tsao, Anne S.; Kantarjian, Hagop; Thomas, Deborah; Giles, Francis; Cortes, Jorge; Garcia-Manero, Guillermo; Huh, Yang; Yang, Ying; Shen, Yu; Albitar, Maher; Estey, Elihu.

In: Leukemia Research, Vol. 28, No. 4, 04.2004, p. 373-378.

Research output: Contribution to journalArticle

Tsao, AS, Kantarjian, H, Thomas, D, Giles, F, Cortes, J, Garcia-Manero, G, Huh, Y, Yang, Y, Shen, Y, Albitar, M & Estey, E 2004, 'C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome', Leukemia Research, vol. 28, no. 4, pp. 373-378. https://doi.org/10.1016/j.leukres.2003.09.008
Tsao, Anne S. ; Kantarjian, Hagop ; Thomas, Deborah ; Giles, Francis ; Cortes, Jorge ; Garcia-Manero, Guillermo ; Huh, Yang ; Yang, Ying ; Shen, Yu ; Albitar, Maher ; Estey, Elihu. / C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome. In: Leukemia Research. 2004 ; Vol. 28, No. 4. pp. 373-378.
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AU - Cortes, Jorge

AU - Garcia-Manero, Guillermo

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