C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome

Anne S. Tsao, Hagop Kantarjian, Deborah Thomas, Francis Giles, Jorge Cortes, Guillermo Garcia-Manero, Yang Huh, Ying Yang, Yu Shen, Maher Albitar, Elihu Estey

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We hypothesize that c-kit expression may be associated with disease-specific features and have prognostic value in acute leukemias. In acute lymphocytic leukemia (ALL), higher levels of c-kit expression predicted lower complete response (CR) rates, suggesting that these patients may benefit from acute myelogenous leukemia (AML) therapy. Despite a negative association with the Philadelphia-chromosome, there was no correlation with disease-free survival (DFS) in CR. In AML, c-kit was associated with older age and cytogenetic abnormality t(-5, -7). Consequently higher levels of c-kit predicted lower CR rates. However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalLeukemia Research
Volume28
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

Keywords

  • Acute lymphocytic leukemia (ALL)
  • Acute myelogenous leukemia (AML)
  • C-kit
  • Martingale residual plots

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Tsao, A. S., Kantarjian, H., Thomas, D., Giles, F., Cortes, J., Garcia-Manero, G., Huh, Y., Yang, Y., Shen, Y., Albitar, M., & Estey, E. (2004). C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome. Leukemia Research, 28(4), 373-378. https://doi.org/10.1016/j.leukres.2003.09.008