C3-targeted therapy in periodontal disease: moving closer to the clinic

Contributing authors

1 Scopus citations

Abstract

Complement plays a key role in immunosurveillance and homeostasis. When dysregulated or overactivated, complement can become a pathological effector, as seen in several inflammatory disorders, including periodontal disease. Recently, clinical correlative studies and preclinical mechanistic investigations have collectively demonstrated that complement is hyperactivated during periodontitis and that targeting its central component (C3) provides therapeutic benefit in nonhuman primates (NHPs). The preclinical efficacy of a C3-targeted drug candidate combined with excellent safety and pharmacokinetic profiles supported its use in a recent Phase IIa clinical study in which C3 inhibition resolved gingival inflammation in patients with periodontal disease. We posit that C3-targeted intervention might represent a novel and transformative host-modulation therapy meriting further investigation in Phase III clinical trials for the treatment of periodontitis.

Original languageEnglish (US)
Pages (from-to)856-864
Number of pages9
JournalTrends in Immunology
Volume42
Issue number10
DOIs
StatePublished - Oct 2021

Fingerprint

Dive into the research topics of 'C3-targeted therapy in periodontal disease: moving closer to the clinic'. Together they form a unique fingerprint.

Cite this