Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure

Eric Jacques Belin de Chantemele, Ludovic Pascaud, Marc Antoine Custaud, Arnaud Capri, Francis Louisy, Guido Ferretti, Claude Gharib, Philippe Arbeille

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The objectives to determine both the contribution to orthostatic intolerance (OI) of calf venous volume during a stand-test, and the effects of a combined eccentric-concentric resistance exercise countermeasure on both vein response to orthostatic test and OI, after 90-day head-down tilt bed-rest (HDT). The subjects consisted of a control group (Co-gr, n = 9) and an exercise countermeasure group (CM-gr, n = 9). Calf volume and vein cross-sectional area (CSA) were assessed by plethysmography and echography during pre- and post-HDT stand-tests. From supine to standing (post-HDT), the tibial and gastronemius vein CSA increased significantly in intolerant subjects (tibial vein, +122% from pre-HDT; gastronemius veins, +145%; P < 0.05) whereas it did not in tolerant subjects. Intolerant subjects tended to have a higher increase in calf filling volume than tolerant subjects, in both sitting and standing positions. The countermeasure did not reduce OI. Absolute calf volume decreased similarly in both groups. Tibial and gastrocnemius vein CSA at rest did not change during HDT in either group. During the post-HDT stand-test, the calf filling volume increased more in the CM-gr than in the Co-gr both in the sitting (+ 1.3 ± 5.1%, vs. -7.3 ± 4.3%; P < 0.05) and the standing positions (+56.1 ± 23.7% vs. + 1.6 ± 9.6%; P < 0.05). The volume ejected by the muscle venous pump increased only in the CM-gr (+38.3 ± 21.8%). This study showed that intolerant subjects had a higher increase in vein CSA in the standing position and a tendency to present a higher calf filling volume in the sitting and standing positions. It also showed that a combined eccentric-concentric resistance exercise counter-measure had no effects on either post-HDT OI or on the venous parameters related to it.

Original languageEnglish (US)
Pages (from-to)611-622
Number of pages12
JournalJournal of Physiology
Volume561
Issue number2
DOIs
StatePublished - Dec 1 2004

Fingerprint

Bed Rest
Orthostatic Intolerance
Posture
Veins
Head-Down Tilt
Plethysmography
Ultrasonography
Muscles
Control Groups

ASJC Scopus subject areas

  • Physiology

Cite this

Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure. / Belin de Chantemele, Eric Jacques; Pascaud, Ludovic; Custaud, Marc Antoine; Capri, Arnaud; Louisy, Francis; Ferretti, Guido; Gharib, Claude; Arbeille, Philippe.

In: Journal of Physiology, Vol. 561, No. 2, 01.12.2004, p. 611-622.

Research output: Contribution to journalArticle

Belin de Chantemele, Eric Jacques ; Pascaud, Ludovic ; Custaud, Marc Antoine ; Capri, Arnaud ; Louisy, Francis ; Ferretti, Guido ; Gharib, Claude ; Arbeille, Philippe. / Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure. In: Journal of Physiology. 2004 ; Vol. 561, No. 2. pp. 611-622.
@article{d014aa905cca4fe2a69985862587ffe7,
title = "Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure",
abstract = "The objectives to determine both the contribution to orthostatic intolerance (OI) of calf venous volume during a stand-test, and the effects of a combined eccentric-concentric resistance exercise countermeasure on both vein response to orthostatic test and OI, after 90-day head-down tilt bed-rest (HDT). The subjects consisted of a control group (Co-gr, n = 9) and an exercise countermeasure group (CM-gr, n = 9). Calf volume and vein cross-sectional area (CSA) were assessed by plethysmography and echography during pre- and post-HDT stand-tests. From supine to standing (post-HDT), the tibial and gastronemius vein CSA increased significantly in intolerant subjects (tibial vein, +122{\%} from pre-HDT; gastronemius veins, +145{\%}; P < 0.05) whereas it did not in tolerant subjects. Intolerant subjects tended to have a higher increase in calf filling volume than tolerant subjects, in both sitting and standing positions. The countermeasure did not reduce OI. Absolute calf volume decreased similarly in both groups. Tibial and gastrocnemius vein CSA at rest did not change during HDT in either group. During the post-HDT stand-test, the calf filling volume increased more in the CM-gr than in the Co-gr both in the sitting (+ 1.3 ± 5.1{\%}, vs. -7.3 ± 4.3{\%}; P < 0.05) and the standing positions (+56.1 ± 23.7{\%} vs. + 1.6 ± 9.6{\%}; P < 0.05). The volume ejected by the muscle venous pump increased only in the CM-gr (+38.3 ± 21.8{\%}). This study showed that intolerant subjects had a higher increase in vein CSA in the standing position and a tendency to present a higher calf filling volume in the sitting and standing positions. It also showed that a combined eccentric-concentric resistance exercise counter-measure had no effects on either post-HDT OI or on the venous parameters related to it.",
author = "{Belin de Chantemele}, {Eric Jacques} and Ludovic Pascaud and Custaud, {Marc Antoine} and Arnaud Capri and Francis Louisy and Guido Ferretti and Claude Gharib and Philippe Arbeille",
year = "2004",
month = "12",
day = "1",
doi = "10.1113/jphysiol.2004.069468",
language = "English (US)",
volume = "561",
pages = "611--622",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure

AU - Belin de Chantemele, Eric Jacques

AU - Pascaud, Ludovic

AU - Custaud, Marc Antoine

AU - Capri, Arnaud

AU - Louisy, Francis

AU - Ferretti, Guido

AU - Gharib, Claude

AU - Arbeille, Philippe

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The objectives to determine both the contribution to orthostatic intolerance (OI) of calf venous volume during a stand-test, and the effects of a combined eccentric-concentric resistance exercise countermeasure on both vein response to orthostatic test and OI, after 90-day head-down tilt bed-rest (HDT). The subjects consisted of a control group (Co-gr, n = 9) and an exercise countermeasure group (CM-gr, n = 9). Calf volume and vein cross-sectional area (CSA) were assessed by plethysmography and echography during pre- and post-HDT stand-tests. From supine to standing (post-HDT), the tibial and gastronemius vein CSA increased significantly in intolerant subjects (tibial vein, +122% from pre-HDT; gastronemius veins, +145%; P < 0.05) whereas it did not in tolerant subjects. Intolerant subjects tended to have a higher increase in calf filling volume than tolerant subjects, in both sitting and standing positions. The countermeasure did not reduce OI. Absolute calf volume decreased similarly in both groups. Tibial and gastrocnemius vein CSA at rest did not change during HDT in either group. During the post-HDT stand-test, the calf filling volume increased more in the CM-gr than in the Co-gr both in the sitting (+ 1.3 ± 5.1%, vs. -7.3 ± 4.3%; P < 0.05) and the standing positions (+56.1 ± 23.7% vs. + 1.6 ± 9.6%; P < 0.05). The volume ejected by the muscle venous pump increased only in the CM-gr (+38.3 ± 21.8%). This study showed that intolerant subjects had a higher increase in vein CSA in the standing position and a tendency to present a higher calf filling volume in the sitting and standing positions. It also showed that a combined eccentric-concentric resistance exercise counter-measure had no effects on either post-HDT OI or on the venous parameters related to it.

AB - The objectives to determine both the contribution to orthostatic intolerance (OI) of calf venous volume during a stand-test, and the effects of a combined eccentric-concentric resistance exercise countermeasure on both vein response to orthostatic test and OI, after 90-day head-down tilt bed-rest (HDT). The subjects consisted of a control group (Co-gr, n = 9) and an exercise countermeasure group (CM-gr, n = 9). Calf volume and vein cross-sectional area (CSA) were assessed by plethysmography and echography during pre- and post-HDT stand-tests. From supine to standing (post-HDT), the tibial and gastronemius vein CSA increased significantly in intolerant subjects (tibial vein, +122% from pre-HDT; gastronemius veins, +145%; P < 0.05) whereas it did not in tolerant subjects. Intolerant subjects tended to have a higher increase in calf filling volume than tolerant subjects, in both sitting and standing positions. The countermeasure did not reduce OI. Absolute calf volume decreased similarly in both groups. Tibial and gastrocnemius vein CSA at rest did not change during HDT in either group. During the post-HDT stand-test, the calf filling volume increased more in the CM-gr than in the Co-gr both in the sitting (+ 1.3 ± 5.1%, vs. -7.3 ± 4.3%; P < 0.05) and the standing positions (+56.1 ± 23.7% vs. + 1.6 ± 9.6%; P < 0.05). The volume ejected by the muscle venous pump increased only in the CM-gr (+38.3 ± 21.8%). This study showed that intolerant subjects had a higher increase in vein CSA in the standing position and a tendency to present a higher calf filling volume in the sitting and standing positions. It also showed that a combined eccentric-concentric resistance exercise counter-measure had no effects on either post-HDT OI or on the venous parameters related to it.

UR - http://www.scopus.com/inward/record.url?scp=10644274497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10644274497&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.2004.069468

DO - 10.1113/jphysiol.2004.069468

M3 - Article

C2 - 15331681

AN - SCOPUS:10644274497

VL - 561

SP - 611

EP - 622

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 2

ER -