CaMKII Activation State Underlies Synaptic Labile Phase of LTP and Short-Term Memory Formation

Huimin Wang, Ruiben Feng, Lei Wang, Fei Li, Xiaohua Cao, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The labile state of short-term memory has been known for more than a century. It has been frequently reported that immediate postlearning intervention can readily disrupt newly formed memories. However, the molecular and cellular mechanisms underlying the labile state of new memory are not understood. Results: Using a bump-and-hole-based chemical-genetic method, we have rapidly and selectively manipulated αCaMKII activity levels in the mouse forebrain during various stages of the short-term memory processes. We find that a rapid shift in the αCaMKII activation status within the immediate 10 min after learning severely disrupts short-term memory formation. The same manipulation beyond the 15 min after learning has no effect, suggesting a critical time window for CaMKII action. We further show that during this same 10 min time window only, shifting in CaMKII activation state is capable of altering newly established synaptic weights and/or patterns. Conclusion: The initial 10 min of memory formation and long-term potentiation are sensitive to inducible genetic upregulation of αCaMKII activity. Our results suggest that molecular dynamics of CaMKII play an important role in underlying synaptic labile state and representation of short-term memory during this critical time window.

Original languageEnglish (US)
Pages (from-to)1546-1554
Number of pages9
JournalCurrent Biology
Volume18
Issue number20
DOIs
StatePublished - Oct 28 2008

Fingerprint

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Short-Term Memory
Chemical activation
Data storage equipment
Learning
learning
Long-Term Potentiation
Molecular Dynamics Simulation
Prosencephalon
molecular dynamics
Up-Regulation
Molecular dynamics
Weights and Measures
brain
mice

Keywords

  • MOLNEURO

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

CaMKII Activation State Underlies Synaptic Labile Phase of LTP and Short-Term Memory Formation. / Wang, Huimin; Feng, Ruiben; Wang, Lei; Li, Fei; Cao, Xiaohua; Tsien, Joseph Zhuo.

In: Current Biology, Vol. 18, No. 20, 28.10.2008, p. 1546-1554.

Research output: Contribution to journalArticle

Wang, Huimin ; Feng, Ruiben ; Wang, Lei ; Li, Fei ; Cao, Xiaohua ; Tsien, Joseph Zhuo. / CaMKII Activation State Underlies Synaptic Labile Phase of LTP and Short-Term Memory Formation. In: Current Biology. 2008 ; Vol. 18, No. 20. pp. 1546-1554.
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