Can novel Apo A-I polymorphisms be responsible for low HDL in South Asian immigrants?

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is the leading cause of death in the world. Even though its rates have decreased worldwide over the past 30 years, event rates are still high in South Asians. South Asians are known to have low high-density lipoprotein (HDL) levels. The objective of this study was to identify Apolipoprotein A-I (Apo A-I) polymorphisms, the main protein component of HDL and explore its association with low HDL levels in South Asians. A pilot study on 30 South Asians was conducted and 12-h fasting samples for C-reactive protein, total cholesterol, HDL, low-density lipoprotein (LDL), triglycerides, Lipoprotein (a), Insulin, glucose levels, DNA extraction, and sequencing of Apo A-I gene were done. DNA sequencing revealed six novel Apo A-I single nucleotide polymorphisms (SNPs) in South Asians, one of which (rs 35293760, C938T) was significantly associated with low (< 40 mg/dl) HDL levels (P = 0.004). The association was also seen with total cholesterol (P = 0.026) and LDL levels (P = 0.032). This pilot work has highlighted some of the gene-environment associations that could be responsible for low HDL and may be excess CAD in South Asians. Further larger studies are required to explore and uncover these associations that could be responsible for excess CAD risk in South Asians.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalIndian Journal of Human Genetics
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Apolipoprotein A-I
HDL Lipoproteins
LDL Lipoproteins
Coronary Artery Disease
DNA Sequence Analysis
Lipoprotein(a)
C-Reactive Protein
HDL Cholesterol
Genes
Single Nucleotide Polymorphism
Cause of Death
Fasting
Cholesterol
Insulin
Glucose
Proteins

Keywords

  • Coronary artery diseases
  • High density lipoprotein
  • Lipids
  • Risk factors
  • South Asians

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Can novel Apo A-I polymorphisms be responsible for low HDL in South Asian immigrants? / Dodani, Sunita; Dong, Yanbin; Zhu, Haidong; George, Varghese.

In: Indian Journal of Human Genetics, Vol. 14, No. 1, 01.01.2008, p. 9-15.

Research output: Contribution to journalArticle

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