Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants

Fred A. Mettler, David Brenner, C. Norman Coleman, Joseph Michael Kaminski, Ann R. Kennedy, Louis K. Wagner

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

OBJECTIVE. Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION. There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.

Original languageEnglish (US)
Pages (from-to)616-618
Number of pages3
JournalAmerican Journal of Roentgenology
Volume196
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Radiation-Protective Agents
Terrorism
Standard of Care
Medicine
Radiation
Research
Radiation Exposure

Keywords

  • Chemical radioprotectants
  • Radiation risk

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants. / Mettler, Fred A.; Brenner, David; Coleman, C. Norman; Kaminski, Joseph Michael; Kennedy, Ann R.; Wagner, Louis K.

In: American Journal of Roentgenology, Vol. 196, No. 3, 01.03.2011, p. 616-618.

Research output: Contribution to journalReview article

Mettler, Fred A. ; Brenner, David ; Coleman, C. Norman ; Kaminski, Joseph Michael ; Kennedy, Ann R. ; Wagner, Louis K. / Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants. In: American Journal of Roentgenology. 2011 ; Vol. 196, No. 3. pp. 616-618.
@article{f3412902c85343a48b48430567154a72,
title = "Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants",
abstract = "OBJECTIVE. Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION. There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.",
keywords = "Chemical radioprotectants, Radiation risk",
author = "Mettler, {Fred A.} and David Brenner and Coleman, {C. Norman} and Kaminski, {Joseph Michael} and Kennedy, {Ann R.} and Wagner, {Louis K.}",
year = "2011",
month = "3",
day = "1",
doi = "10.2214/AJR.10.4959",
language = "English (US)",
volume = "196",
pages = "616--618",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "3",

}

TY - JOUR

T1 - Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants

AU - Mettler, Fred A.

AU - Brenner, David

AU - Coleman, C. Norman

AU - Kaminski, Joseph Michael

AU - Kennedy, Ann R.

AU - Wagner, Louis K.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - OBJECTIVE. Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION. There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.

AB - OBJECTIVE. Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION. There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.

KW - Chemical radioprotectants

KW - Radiation risk

UR - http://www.scopus.com/inward/record.url?scp=79952260299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952260299&partnerID=8YFLogxK

U2 - 10.2214/AJR.10.4959

DO - 10.2214/AJR.10.4959

M3 - Review article

C2 - 21343505

AN - SCOPUS:79952260299

VL - 196

SP - 616

EP - 618

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 3

ER -