Cancer and the complement cascade

Martin J. Rutkowski, Michael E. Sughrue, Ari J. Kane, Steven A. Mills, Andrew T. Parsa

Research output: Contribution to journalReview articlepeer-review

155 Scopus citations

Abstract

Despite significant research on the role of inflammation and immunosurveillance in the immunologic microenvironment of tumors, little attention has been given to the oncogenic capabilities of the complement cascade. The recent finding that complement may contribute to tumor growth suggests an insidious relationship between complement and cancer, especially in light of evidence that complement facilitates cellular proliferation and regeneration. We address the hypothesis that complement proteins promote carcinogenesis and suggest mechanisms by which complement can drive the fundamental features of cancer. Evidence shows that this diverse family of innate immune proteins facilitates dysregulation of mitogenic signaling pathways, sustained cellular proliferation, angiogenesis, insensitivity to apoptosis, invasion and migration, and escape from immunosurveillance. Given that the traditionally held functions for the complement system include innate immunity and cancer defense, our review suggests a new way of thinking about the role of complement proteins in neoplasia.

Original languageEnglish (US)
Pages (from-to)1453-1465
Number of pages13
JournalMolecular Cancer Research
Volume8
Issue number11
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Oncology
  • Cancer Research

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