Cancer stem cells: Nature versus nurture

Hasan Korkaya, Max S. Wicha

Research output: Contribution to journalShort survey

38 Scopus citations

Abstract

Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.

Original languageEnglish (US)
Pages (from-to)419-421
Number of pages3
JournalNature Cell Biology
Volume12
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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