Cancer stem cells: Nature versus nurture

Hasan Korkaya, Max S. Wicha

Research output: Contribution to journalShort survey

37 Citations (Scopus)

Abstract

Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.

Original languageEnglish (US)
Pages (from-to)419-421
Number of pages3
JournalNature Cell Biology
Volume12
Issue number5
DOIs
StatePublished - May 1 2010

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Neoplastic Stem Cells
Catenins
Adenomatous Polyposis Coli
Hepatocyte Growth Factor
Myofibroblasts
Colonic Neoplasms
Mutation
Neoplasms

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cancer stem cells : Nature versus nurture. / Korkaya, Hasan; Wicha, Max S.

In: Nature Cell Biology, Vol. 12, No. 5, 01.05.2010, p. 419-421.

Research output: Contribution to journalShort survey

Korkaya, Hasan ; Wicha, Max S. / Cancer stem cells : Nature versus nurture. In: Nature Cell Biology. 2010 ; Vol. 12, No. 5. pp. 419-421.
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