Candidate genes for hypertension: Insights from the Dahl S rat

Nathan P. Rudemiller, David L. Mattson

Research output: Contribution to journalReview article

Abstract

Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.

Original languageEnglish (US)
Pages (from-to)F993-F995
JournalAmerican Journal of Physiology - Renal Physiology
Volume309
Issue number12
DOIs
StatePublished - Dec 15 2015
Externally publishedYes

Fingerprint

Inbred Dahl Rats
Hypertension
Mutagenesis
Genes
Genetic Linkage
Medical Genetics
Genetic Association Studies
Therapeutics

Keywords

  • High-salt diet
  • Hypertension
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Candidate genes for hypertension : Insights from the Dahl S rat. / Rudemiller, Nathan P.; Mattson, David L.

In: American Journal of Physiology - Renal Physiology, Vol. 309, No. 12, 15.12.2015, p. F993-F995.

Research output: Contribution to journalReview article

Rudemiller, Nathan P. ; Mattson, David L. / Candidate genes for hypertension : Insights from the Dahl S rat. In: American Journal of Physiology - Renal Physiology. 2015 ; Vol. 309, No. 12. pp. F993-F995.
@article{6c30b4fa65ce414186d04ecc22a955c1,
title = "Candidate genes for hypertension: Insights from the Dahl S rat",
abstract = "Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.",
keywords = "High-salt diet, Hypertension, Single nucleotide polymorphisms",
author = "Rudemiller, {Nathan P.} and Mattson, {David L.}",
year = "2015",
month = "12",
day = "15",
doi = "10.1152/ajprenal.00092.2015",
language = "English (US)",
volume = "309",
pages = "F993--F995",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "12",

}

TY - JOUR

T1 - Candidate genes for hypertension

T2 - Insights from the Dahl S rat

AU - Rudemiller, Nathan P.

AU - Mattson, David L.

PY - 2015/12/15

Y1 - 2015/12/15

N2 - Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.

AB - Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.

KW - High-salt diet

KW - Hypertension

KW - Single nucleotide polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84959205722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959205722&partnerID=8YFLogxK

U2 - 10.1152/ajprenal.00092.2015

DO - 10.1152/ajprenal.00092.2015

M3 - Review article

C2 - 25877508

AN - SCOPUS:84959205722

VL - 309

SP - F993-F995

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 12

ER -