Candidate genes for hypertension: Insights from the Dahl S rat

Nathan P. Rudemiller, David L. Mattson

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.

Original languageEnglish (US)
Pages (from-to)F993-F995
JournalAmerican Journal of Physiology - Renal Physiology
Volume309
Issue number12
DOIs
StatePublished - Dec 15 2015

Keywords

  • High-salt diet
  • Hypertension
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Physiology
  • Urology

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