Capsaicin-induced pain and sensitisation in the postpartum period

Linda Marie Street, L. Harris, R. S. Curry, J. C. Eisenach

Research output: Contribution to journalArticle

Abstract

Background: Recovery from Caesarean delivery in women and surgical nerve injury in animals after delivery is more rapid than expected, an effect reversed in animals by spinal injection of an oxytocin receptor antagonist. We hypothesised that endogenous modulation of acute pain is altered postpartum. Methods: Endogenous inhibition of acute pain in a conditioned pain modulation paradigm or endogenous sensitisation by topical capsaicin was tested in women who were breastfeeding 10–14 days after Caesarean delivery and age-matched controls (n=80 total: 20 per group and 20 per test). The study was powered to detect a difference in area of hyperalgesia after capsaicin of 33%. Capsaicin-evoked pain was recorded in women, and capsaicin-evoked mechanical hypersensitivity was measured in rats 48 h after delivery and in age-matched female and male animals. Results: There was no effect of the postpartum period in the endogenous sensitisation assay in women, and the conditioned pain modulation assay failed to produce analgesia in either group. Postpartum women, however, reported less intense pain than controls at the end of topical capsaicin exposure (1.3 [1.4] vs 2.0 [2.0] on 0–10 verbal scale), and acute hypersensitivity after capsaicin was less in postpartum than control rats (withdrawal threshold 25 [15] vs 3.6 [1] g). Conclusions: These results agree with a recent report that oxytocin may desensitise the transient receptor potential for vanilloid-1 channel, although other explanations, including hormone effects, are possible. These results do not, however, support the inhibition of capsaicin-evoked spinal sensitisation in the postpartum period. Clinical trial registration: NCT01843517.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalBritish Journal of Anaesthesia
Volume122
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Capsaicin
Postpartum Period
Pain
Acute Pain
Hypersensitivity
Oxytocin Receptors
Spinal Injections
Hyperalgesia
Intraoperative Complications
Oxytocin
Breast Feeding
Analgesia
Clinical Trials
Hormones

Keywords

  • Caesarean delivery
  • hyperalgesia
  • nerve injury
  • oxytocin
  • postoperative pain
  • postpartum period

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Capsaicin-induced pain and sensitisation in the postpartum period. / Street, Linda Marie; Harris, L.; Curry, R. S.; Eisenach, J. C.

In: British Journal of Anaesthesia, Vol. 122, No. 1, 01.01.2019, p. 103-110.

Research output: Contribution to journalArticle

Street, Linda Marie ; Harris, L. ; Curry, R. S. ; Eisenach, J. C. / Capsaicin-induced pain and sensitisation in the postpartum period. In: British Journal of Anaesthesia. 2019 ; Vol. 122, No. 1. pp. 103-110.
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