Carcinoid tumors are 15 times more common in patients with Crohn's disease

N. E. West, P. E. Wise, Alan Joseph Herline, R. L. Muldoon, W. V. Chopp, D. A. Schwartz

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: The coexistence of intestinal neoplasms with Crohn's disease (CD) has been reported, but the evidence of an increased risk of carcinoid tumor with Crohn's disease has been mixed. We present 4 patients with CD with associated carcinoid tumor. Methods: The charts of 111 patients with CD who had undergone resection between June 2001 and March 2005 were reviewed. The number of incidental carcinoid tumors in patients who underwent an appendectomy was used as a control. Results: Four cases of carcinoid tumor discovered in patients at resection for CD were identified. None had metastatic disease or carcinoid syndrome. These included 1 cecal (1 mm), 2 appendiceal (3 and 7mm), and 1 transverse colon (7 mm) carcinoid tumors. None of the carcinoid tumors were identified in regions of active Crohn's disease. The incidence of carcinoid tumor in patients with Crohn's disease was 4 of 111 (3.6%). In comparison, 3 of 1199 patients (0.25%) who had appendectomies were identified as having appendiceal carcinoid tumor. Crohn's disease was associated with an increased incidence of carcinoid tumor; OR 14.9 (95% CI 2.5-102.5), P < 0.0001. Conclusions: There was a significantly increased incidence of carcinoid tumor in our Crohn's patients compared to the control patients. None of the carcinoid tumors developed in areas of Crohn's disease. This suggests that the development of carcinoid tumors may be secondary to distant proinflammatory mediators, rather than a local inflammatory effect from adjacent Crohn's disease. Patients with CD may be at increased risk of developing a carcinoid tumor.

Original languageEnglish (US)
Pages (from-to)1129-1134
Number of pages6
JournalInflammatory Bowel Diseases
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2007

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Carcinoid Tumor
Crohn Disease
Appendectomy
Incidence
Intestinal Neoplasms
Transverse Colon

Keywords

  • Carcinoid tumor
  • Crohn's disease
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Cite this

West, N. E., Wise, P. E., Herline, A. J., Muldoon, R. L., Chopp, W. V., & Schwartz, D. A. (2007). Carcinoid tumors are 15 times more common in patients with Crohn's disease. Inflammatory Bowel Diseases, 13(9), 1129-1134. https://doi.org/10.1002/ibd.20172

Carcinoid tumors are 15 times more common in patients with Crohn's disease. / West, N. E.; Wise, P. E.; Herline, Alan Joseph; Muldoon, R. L.; Chopp, W. V.; Schwartz, D. A.

In: Inflammatory Bowel Diseases, Vol. 13, No. 9, 01.09.2007, p. 1129-1134.

Research output: Contribution to journalArticle

West, NE, Wise, PE, Herline, AJ, Muldoon, RL, Chopp, WV & Schwartz, DA 2007, 'Carcinoid tumors are 15 times more common in patients with Crohn's disease', Inflammatory Bowel Diseases, vol. 13, no. 9, pp. 1129-1134. https://doi.org/10.1002/ibd.20172
West NE, Wise PE, Herline AJ, Muldoon RL, Chopp WV, Schwartz DA. Carcinoid tumors are 15 times more common in patients with Crohn's disease. Inflammatory Bowel Diseases. 2007 Sep 1;13(9):1129-1134. https://doi.org/10.1002/ibd.20172
West, N. E. ; Wise, P. E. ; Herline, Alan Joseph ; Muldoon, R. L. ; Chopp, W. V. ; Schwartz, D. A. / Carcinoid tumors are 15 times more common in patients with Crohn's disease. In: Inflammatory Bowel Diseases. 2007 ; Vol. 13, No. 9. pp. 1129-1134.
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