Carcinoma of the hypopharynx

Christine G. Gourin, David J Terris

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Despite advances in surgical and nonsurgical treatment, overall survival rates for patients who have hypopharyngeal carcinoma have not improved, and this disease still has a poor prognosis. The best results are obtained with multimodality therapy, but at best, two thirds of patients are palliated rather than cured of disease. Radical surgery with postoperative radiation therapy remains the standard of care. Organ preservation strategies have not been as successful in hypopharyngeal cancer as for cancers of other head and neck sites. Chemoradiation is an effective alternative method of aggressive treatment but may be associated with significant dysfunction of the end organ when preservation is possible. Because of poor long-term survival rates, local control remains the most important factor in planning treatment, to provide meaningful palliation and best possible quality of life.

Original languageEnglish (US)
Pages (from-to)81-98
Number of pages18
JournalSurgical Oncology Clinics of North America
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Hypopharynx
Organ Preservation
Carcinoma
Survival Rate
Hypopharyngeal Neoplasms
Therapeutics
Standard of Care
Head and Neck Neoplasms
Radiotherapy
Quality of Life

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Carcinoma of the hypopharynx. / Gourin, Christine G.; Terris, David J.

In: Surgical Oncology Clinics of North America, Vol. 13, No. 1, 01.01.2004, p. 81-98.

Research output: Contribution to journalReview article

Gourin, Christine G. ; Terris, David J. / Carcinoma of the hypopharynx. In: Surgical Oncology Clinics of North America. 2004 ; Vol. 13, No. 1. pp. 81-98.
@article{1ef02a2a1f31497c8687178dc240b263,
title = "Carcinoma of the hypopharynx",
abstract = "Despite advances in surgical and nonsurgical treatment, overall survival rates for patients who have hypopharyngeal carcinoma have not improved, and this disease still has a poor prognosis. The best results are obtained with multimodality therapy, but at best, two thirds of patients are palliated rather than cured of disease. Radical surgery with postoperative radiation therapy remains the standard of care. Organ preservation strategies have not been as successful in hypopharyngeal cancer as for cancers of other head and neck sites. Chemoradiation is an effective alternative method of aggressive treatment but may be associated with significant dysfunction of the end organ when preservation is possible. Because of poor long-term survival rates, local control remains the most important factor in planning treatment, to provide meaningful palliation and best possible quality of life.",
author = "Gourin, {Christine G.} and Terris, {David J}",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/S1055-3207(03)00122-4",
language = "English (US)",
volume = "13",
pages = "81--98",
journal = "Surgical Oncology Clinics of North America",
issn = "1055-3207",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Carcinoma of the hypopharynx

AU - Gourin, Christine G.

AU - Terris, David J

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Despite advances in surgical and nonsurgical treatment, overall survival rates for patients who have hypopharyngeal carcinoma have not improved, and this disease still has a poor prognosis. The best results are obtained with multimodality therapy, but at best, two thirds of patients are palliated rather than cured of disease. Radical surgery with postoperative radiation therapy remains the standard of care. Organ preservation strategies have not been as successful in hypopharyngeal cancer as for cancers of other head and neck sites. Chemoradiation is an effective alternative method of aggressive treatment but may be associated with significant dysfunction of the end organ when preservation is possible. Because of poor long-term survival rates, local control remains the most important factor in planning treatment, to provide meaningful palliation and best possible quality of life.

AB - Despite advances in surgical and nonsurgical treatment, overall survival rates for patients who have hypopharyngeal carcinoma have not improved, and this disease still has a poor prognosis. The best results are obtained with multimodality therapy, but at best, two thirds of patients are palliated rather than cured of disease. Radical surgery with postoperative radiation therapy remains the standard of care. Organ preservation strategies have not been as successful in hypopharyngeal cancer as for cancers of other head and neck sites. Chemoradiation is an effective alternative method of aggressive treatment but may be associated with significant dysfunction of the end organ when preservation is possible. Because of poor long-term survival rates, local control remains the most important factor in planning treatment, to provide meaningful palliation and best possible quality of life.

UR - http://www.scopus.com/inward/record.url?scp=1542357322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542357322&partnerID=8YFLogxK

U2 - 10.1016/S1055-3207(03)00122-4

DO - 10.1016/S1055-3207(03)00122-4

M3 - Review article

VL - 13

SP - 81

EP - 98

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

SN - 1055-3207

IS - 1

ER -