Cardiac electrophysiological effects of citalopram in guinea pig papillary muscle: Comparison with clomipramine

Pál Pacher, Zsolt Bagi, Zoltán Lakó-Futó, Zoltán Ungvári, Péter P. Nánási, Valéria Kecskeméti

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effect of citalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, was studied on cardiac action potential configuration and compared with that of the tricyclic antidepressant (TCA) clomipramine. Conventional microelectrode techniques were used in right ventricular papillary muscle preparations of the guinea pig. Citalopram caused a concentration-dependent (10-100 μM) shortening of action potential duration (APD), depression of plateau and overshoot potential, and reduction of maximum velocity of depolarization (V(max)). No significant changes in resting membrane potential were observed. Similar results were obtained with clomipramine; however, reduction of V(max) and overshoot was more pronounced with clomipramine, whereas citalopram caused relatively greater shortening of APD. Effects of both drugs were partly reversible. The results indicate that the SSRI antidepressant citalopram, similarly to TCA compounds, alters cardiac action potential configuration in guinea pig ventricular muscle, probably owing to inhibition of cardiac Na+ and Ca2+ channels. Differences in cardiac side effects of the two drugs may be related to their different actions on cardiac action potential configuration. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalGeneral Pharmacology
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Antidepressant drugs
  • Cardiac action potential
  • Cardiac ion channels
  • Citalopram
  • Clomipramine
  • Electrophysiology

ASJC Scopus subject areas

  • Pharmacology

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