TY - JOUR
T1 - Cardiac injury in short duration anoxia and modification by diltiazem, a calcium channel blocking agent
AU - Ashraf, Muhammad
AU - Rahamathulla, Pacha Meyian
N1 - Funding Information:
sity of Cincinnati ported by Grant HL23597 from the National Institutes of Health, and Research Career lic Health 1983; revised 19, 1983.
PY - 1984
Y1 - 1984
N2 - The protective effects of diltiazem were studied in isolated perfused rat hearts after 10, 20 and 30 minutes of anoxia and 10 minutes of reoxygenation. The hearts were treated with diltiazem, 4 mg/liter, during anoxia and reoxygenation. The myocardial tissue was processed for electron microscopy and tissue calcium was measured. Four types of cell injury ranging from normal to severe were observed. The prominent morphologic changes in the nondiltiazem-treated tissue were contraction bands, distortion and calcification of mitochondria and loss of glycogen. In the treated group, a partial reduction of cell injury was noted. The mitochondria were usually well preserved, but contraction bands were present. The tissue calcium decreased after treatment with diltiazem. The observations suggest that diltiazem decreases tissue calcium and protects mitochondria more than other cellular components against calcium overload, and this protection may be responsible for the beneficial action of this drug.
AB - The protective effects of diltiazem were studied in isolated perfused rat hearts after 10, 20 and 30 minutes of anoxia and 10 minutes of reoxygenation. The hearts were treated with diltiazem, 4 mg/liter, during anoxia and reoxygenation. The myocardial tissue was processed for electron microscopy and tissue calcium was measured. Four types of cell injury ranging from normal to severe were observed. The prominent morphologic changes in the nondiltiazem-treated tissue were contraction bands, distortion and calcification of mitochondria and loss of glycogen. In the treated group, a partial reduction of cell injury was noted. The mitochondria were usually well preserved, but contraction bands were present. The tissue calcium decreased after treatment with diltiazem. The observations suggest that diltiazem decreases tissue calcium and protects mitochondria more than other cellular components against calcium overload, and this protection may be responsible for the beneficial action of this drug.
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U2 - 10.1016/S0735-1097(84)80182-5
DO - 10.1016/S0735-1097(84)80182-5
M3 - Article
C2 - 6707374
AN - SCOPUS:0021326344
SN - 0735-1097
VL - 3
SP - 1237
EP - 1244
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 5
ER -