Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience

Deirdre O'Mahony, Indranil Debnath, John Edward Janik, Dara Aisner, Elaine Jaffe, Thomas Waldmann, John Morris

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Malignant cardiac involvement is rare in patients with human T cell lymphotrophic virus type-1-associated adult T cell leukemia/lymphoma (ATLL). We report a single institution experience of eight patients with pathologically documented cardiac involvement with ATLL. Pericardial effusion and tamponade, cardiac valvular infiltration, valve leaflet tumor nodules and endocardial and myocardial tumors were observed. Cardiac involvement with ATLL was most often identified post-mortem; however, three cases were diagnosed clinically. All but one of the patients had the acute or lymphomatous subtypes of ATLL and had progressed through at least one prior systemic therapy. Patients with ATLL-related cardiac disease were also found to have pulmonary involvement suggesting that this may be a sign of increased risk of cardiac involvement. One patient with the chronic form of ATLL remains alive 10 years after undergoing cardiac valve replacement.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalLeukemia and Lymphoma
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2008

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Adult T Cell Leukemia Lymphoma
Viruses
T-Lymphocytes
Cardiac Tamponade
Pericardial Effusion
Heart Valves
Heart Diseases
Neoplasms
Lung

Keywords

  • Adult T cell leukemia/lymphoma
  • Cardiac neoplasm
  • HTLV-1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma : The NIH experience. / O'Mahony, Deirdre; Debnath, Indranil; Janik, John Edward; Aisner, Dara; Jaffe, Elaine; Waldmann, Thomas; Morris, John.

In: Leukemia and Lymphoma, Vol. 49, No. 3, 01.03.2008, p. 439-446.

Research output: Contribution to journalArticle

O'Mahony, Deirdre ; Debnath, Indranil ; Janik, John Edward ; Aisner, Dara ; Jaffe, Elaine ; Waldmann, Thomas ; Morris, John. / Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma : The NIH experience. In: Leukemia and Lymphoma. 2008 ; Vol. 49, No. 3. pp. 439-446.
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