Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats

Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Ansarullah, Sanjay S. Karn, Jigar D. Shah, Dipak K. Patel, Sunita P. Salunke, Geeta S. Padate, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalExperimental and Toxicologic Pathology
Volume63
Issue number4
DOIs
StatePublished - May 2011

Keywords

  • Isoproterenol
  • Myocardial infarction
  • Sida rhomboidea. Roxb

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology

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    Thounaojam, M. C., Jadeja, R. N., Ansarullah, Karn, S. S., Shah, J. D., Patel, D. K., Salunke, S. P., Padate, G. S., Devkar, R. V., & Ramachandran, A. V. (2011). Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats. Experimental and Toxicologic Pathology, 63(4), 351-356. https://doi.org/10.1016/j.etp.2010.02.010