Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats

Sharyn M. Fitzgerald, Jeffrey R. Henegar, Michael W. Brands, Lisa K. Henegar, John E. Hall

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study examined the cardiovascular, renal, and hormonal responses of dietary-induced obesity in Osborne-Mendel (OM) rats. Male OM rats were fed either a low (LF; n = 10)- or high-fat (HF; n = 11) diet for 17 wk. During week 15 of the study, arterial pressure was measured directly, 24 h/day, from chronically indwelling catheters. Body and kidney weights were 46 ± 5 and 33 ± 5% greater, respectively, in rats fed HF vs. LF diet. Left and right ventricular weights were also greater in rats fed HF diet (21 ± 7 and 36 ± 6%, respectively). Direct measurement of arterial pressure revealed only a slight increase in mean arterial pressure (88 ± 1 in rats fed HF diet vs. 85 ± 1 mmHg in rats fed LF diet), whereas there was no difference in resting heart rate between the two groups. Consumption of HF diet was also associated with a 3.5-fold increase in plasma insulin, a 16 ± 4% higher blood glucose, and a 40 ± 6% reduction in plasma renin activity compared with LF-fed rats. Thus feeding OM rats HF diet led to obesity, cardiac and renal hypertrophy, and hyperinsulinemia but only a slight increase in mean arterial pressure.

Original languageEnglish (US)
Pages (from-to)R547-R552
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume281
Issue number2 50-2
StatePublished - Aug 29 2001
Externally publishedYes

Fingerprint

High Fat Diet
Kidney
Diet
Arterial Pressure
Obesity
Indwelling Catheters
Hyperinsulinism
Cardiomegaly
Renin
Blood Glucose
Heart Rate
Fats
Body Weight
Insulin
Weights and Measures

Keywords

  • Cardiac hypertrophy
  • Hypertension

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. / Fitzgerald, Sharyn M.; Henegar, Jeffrey R.; Brands, Michael W.; Henegar, Lisa K.; Hall, John E.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 281, No. 2 50-2, 29.08.2001, p. R547-R552.

Research output: Contribution to journalArticle

Fitzgerald, Sharyn M. ; Henegar, Jeffrey R. ; Brands, Michael W. ; Henegar, Lisa K. ; Hall, John E. / Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001 ; Vol. 281, No. 2 50-2. pp. R547-R552.
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