Cardiovascular toxicity of tyrosine kinase inhibitors

Elie Mouhayar, Jean Bernard Durand, Jorge Cortes

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Introduction: Small-molecule tyrosine kinase inhibitors (TKIs) have revolutionized the management of many malignancies. However, they also have been shown to be associated with a certain degree of cardiovascular side effects that are often reversible. Areas covered: As the number of new TKIs continues to grow, it is expected that clinicians will be facing the challenge of early detection and 10 management of these side effects while balancing the risk-benefit ratios of continuing with life-saving cancer therapy medications. This review will present the current knowledge related to incidence and proposed mechanisms of cardiovascular side effects of TKIs and also discuss treatment recommendations when available Expert opinion: We will present and discuss available data and suggest recommendations related to patient monitoring and early identification of TKIs related cardiovascular toxities.

Original languageEnglish (US)
Pages (from-to)687-696
Number of pages10
JournalExpert Opinion on Drug Safety
Volume12
Issue number5
DOIs
Publication statusPublished - Sep 1 2013
Externally publishedYes

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Keywords

  • Biomarkers
  • Cardiomyopathy
  • Cardiovascular toxicity
  • Hypertension
  • Thrombosis
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Pharmacology (medical)

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