Carnitine homeostasis, mitochondrial function and cardiovascular disease

Shruti Sharma, Stephen M. Black

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.

Original languageEnglish (US)
Pages (from-to)e31-e39
JournalDrug Discovery Today: Disease Mechanisms
Volume6
Issue number1-4
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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