Carnitine homeostasis, mitochondrial function and cardiovascular disease

Shruti Sharma, Stephen Matthew Black

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.

Original languageEnglish (US)
JournalDrug Discovery Today: Disease Mechanisms
Volume6
Issue number1-4
DOIs
StatePublished - Mar 10 2009

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Mitochondrial Diseases
Carnitine
Homeostasis
Cardiovascular Diseases
Fatty Acids
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Carnitine homeostasis, mitochondrial function and cardiovascular disease. / Sharma, Shruti; Black, Stephen Matthew.

In: Drug Discovery Today: Disease Mechanisms, Vol. 6, No. 1-4, 10.03.2009.

Research output: Contribution to journalReview article

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