Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles

Vadivel Ganapathy, Joseph Mendicino, David H. Pashley, Frederick H. Leibach

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Renal brush border vesicles prepared from rabbit were shown to transport intact glycyl-L-proline into the intravesicular space by a Na+-independent, carrier-mediated process. The kinetics of hydrolysis of glycyl-L-proline by the vesicles showed that this dipeptide was extremely resistant to hydrolysis. The intravesicular concentration of glycyl-L-proline was the same in both NaCl and KCl media. Dipeptide uptake into the vesicles appeared to be via carrier-mediated transport down a concentration gradient.

Original languageEnglish (US)
Pages (from-to)1133-1139
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume97
Issue number3
DOIs
StatePublished - Dec 16 1980

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glycylproline
Carrier transport
Brushes
Microvilli
Dipeptides
Kidney
Hydrolysis
Rabbits
Kinetics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles. / Ganapathy, Vadivel; Mendicino, Joseph; Pashley, David H.; Leibach, Frederick H.

In: Biochemical and Biophysical Research Communications, Vol. 97, No. 3, 16.12.1980, p. 1133-1139.

Research output: Contribution to journalArticle

Ganapathy, Vadivel ; Mendicino, Joseph ; Pashley, David H. ; Leibach, Frederick H. / Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles. In: Biochemical and Biophysical Research Communications. 1980 ; Vol. 97, No. 3. pp. 1133-1139.
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