Case-control association study of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population

Fulei Tang, Mei Qu, Lifang Wang, Yan Ruan, Tianlan Lu, Handi Zhang, Zhonghua Liu, Weihua Yue, Dai Zhang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Converging evidence from imaging, microarray, genetic, and other studies suggests that abnormalities in myelin may play a role in schizophrenia. The expression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP), which is used as a myelin marker, has been reported to be reduced in the schizophrenic brain. A synonymous genetic variation in the CNP gene, rs2070106, has recently been shown to be associated with schizophrenia in Caucasians. The present study investigates whether this finding can be replicated in the Han Chinese population. We performed an association analysis of four ht-SNPs in the CNP gene in a Chinese sample consisting of 426 schizophrenic patients and 439 healthy controls. We did not find any significant differences in any genotypic, allelic or haplotypic distributions between patients and controls. Therefore, this study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Volume416
Issue number2
DOIs
StatePublished - Apr 12 2007

Keywords

  • Haplotype
  • Myelination
  • Oligodendrocyte

ASJC Scopus subject areas

  • Neuroscience(all)

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